A Case of Cunninghamella bertholettiae Rhino-cerebral Infection in a Leukaemic Patient and Review of Recent Published Studies
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Cunninghamella bertholletiae infection occurs most frequently in neutropenic patients affected by haematological malignancies, is associated with an unfavourable outcome. We report a case of rhino-mastoidal fungal infection in a leukaemic patient. Bioptical tissue cultures yield the isolation of a mould with typical properties of Cunninghamella species. Liposomal amphotericin B (L-Amb) therapy combined with surgical intervention brought the lesion to recovery. Nevertheless, the patient died 14 days after bone marrow transplantation (BMT) from bacterial sepsis. Mastoiditis was documented at CT-scan. The conditioning regimen probably caused the reactivation of the Cunninghamella infection that led to the patient’s fatal outcome; fungal hyphae were detected after autopsy of brain and lung tissue.
- Maloisel, F, Dufour, P, Waller, J (2000) Cunninghamella bertholletiae: an uncommon agent of opportunistic fungal infection: case report and review of the literature. Bone Marrow Transplant 25: pp. 1213-6 CrossRef
- Passos, XS, Sales, WS, Maciel, PJ, Costa, CR, Ferreira, DM, do Silva, MR. (2006) Nosocomial invasive infection caused by Cunninghamella bertolletiae: case report. Mycopathologia 161: pp. 33-5 CrossRef
- Sands, JM, Macher, AM, Ley, TJ, Nienhuis, AW. (1995) Disseminated infections caused by Cunninghamella bertolletiae in a patient with β-thalassemia. Ann Intern Med. 102: pp. 59-63
- Zeilender, S, Drenning, S, Glauser, FL, Bechard, D. (1990) Fatal Cunninghamella bertolletiae infection in an immunocompetent patient. Chest 97: pp. 1482-3 CrossRef
- Hutter, RVP. (1959) Phycomicetes infection (mucormicosis) in cancer patients: complication of therapy. Cancer 12: pp. 330-50 CrossRef
- Ribes, JA, Vanover-Sams, CL, Baker, DJ. (2000) Zigomycetes in human disease. Clin Microbiol Rev. 13: pp. 236-301 CrossRef
- Boyce, JM, Lawson, LA, Lockwood, WR, Hughes, JR. (1981) Cunninghamella bertholletiae wound infection of probable nosocomial origin. South Med J. 74: pp. 1132-5
- Kontoyiannis, DP, Vartivarian, S, Anaissie, EJ, Samonis, G, Bodet, GP, Rinaldi, M. (1994) Infections due to Cunninghamella bertholletiae in patients with cancer: reports of three cases and review. Clin Infect Dis. 18: pp. 925-8
- Pimentel, JD, Dreyer, G, Lum, GD. (2006) Peritonitis due to Cunninghamella bertholletiae in a patient undergoing continuous ambulatory peritoneal dialysis. J Med Microbiol 55: pp. 115-8 CrossRef
- Sivakumar, S, Mathews, MS, George, B. (2005) Cunninghamella pneumonia in postbone marrow transplant patient: first case report from India. Mycoses 48: pp. 360-2 CrossRef
- Ortín X, Escoda L, Llorente A, et al. Cunninghamella bertholletiae infection (mucormycosis) in a patient with acute T-cell lymphoblastic leukemia. Leuk Lymphoma. 2004;45(3):617–20.
- Quinio, D, Karam, A, Leroy, JP (2004) Zygomycosis caused by Cunninghamella bertholletiae in a kidney transplant recipient. Med Mycol. 42: pp. 177-80 CrossRef
- Zhang, (2002) Endocarditis and hemorrhagic stroke caused by Cunninghamella bertholletiae infection after kidney transplantation. Am J Kidney Dis. 40: pp. 842-6 CrossRef
- Singh, J, Rimek, D, Kappe, R. (2005) In vitro susceptibility of 15 strains of zygomycetes to nine antifungal agents as determined by the NCCLS M38-A microdilution method. Mycoses 48: pp. 246-50 CrossRef
- Guinea, J, Pelaez, T, Alcala, L, Bouza, E. (2006) Comparison of sensititre yeastone with the NCCLS M38-A microdilution method to determine the activity of amphotericin B, voriconazole, and itraconazole against clinical isolates of Aspergillus fumigatus. Diagn Microbiol Infect Dis. 56: pp. 53-5 CrossRef
- McNulty, JS. (1982) Rhinocerebral mucormycosis: predisposing factors. Laryngoscope 92: pp. 1140-3 CrossRef
- Honda A Kamei K, Unno H, Hiroshima K, Kuriyama T, Miyaji M. A murine model of zygomycosis by Cunninghamella bertholletiae. Mycopathologia. 1998–1999;144(3):141–6.
- Almyroudis, NG, Sutton, DA, Fothergill, AW, Rinaldi, MG, Kusne, S. (2007) In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. Antimicrob Agents Chemother. 51: pp. 2587-90 CrossRef
- Vazquez L, Mateos JJ, Sanz-Rodriguez C, Perez E, Caballero D, San Miguel JF. Successful treatment of rhinocerebral zygomycosis with a combination of caspofungin and liposomal amphotericin B. Haematologica. 2005;90(12):ECR39.
- Mazade MA, Margolin JF, Rossmann SN, Edwards MS. Survival from pulmonary infection with Cunninghamella bertholletiae: case report and review of the literature. Pediatr Infect Dis J. 1998;17(9):835–9.
- Ng, TT, Campbell, CK, Rothera, M, Houghton, JB, Hughes, D, Denning, DW. (1994) Successful treatment of sinusitis caused by Cunninghamella bertholletiae. Clin Infect Dis. 19: pp. 313-6
- A Case of Cunninghamella bertholettiae Rhino-cerebral Infection in a Leukaemic Patient and Review of Recent Published Studies
Volume 165, Issue 6 , pp 407-410
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- L-amphotericin B
- Cunninghamella bertholettiae
- Industry Sectors
- Author Affiliations
- 1. Division of Infectious Diseases, S. Martino Hospital, University of Genoa School of Medicine, 16132, Genoa, Italy
- 2. Section of Microbiology, S. Martino Hospital, University of Genoa School of Medicine, Genoa, Italy
- 3. Division of Haematology, S. Martino Hospital, University of Genoa School of Medicine, Genoa, Italy