Article

Mycopathologia

, 162:45

First online:

Species Distribution and Antifungal Susceptibility Profile of Oral Candida Isolates from HIV-infected Patients in the Antiretroviral Therapy Era

  • Carolina Rodrigues CostaAffiliated withInstituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás
  • , Janine Aquino de LemosAffiliated withInstituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás
  • , Xisto Sena PassosAffiliated withInstituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás
  • , Crystiane Rodrigues de AraújoAffiliated withInstituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás
  • , Ana Joaquina CohenAffiliated withHospital de Doenças Tropicais de Goiás
  • , Lúcia Kioko Hasimoto e SouzaAffiliated withInstituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás
  • , Maria do Rosário Rodrigues SilvaAffiliated withInstituto de Patologia Tropical e Saúde Pública da, Universidade Federal de GoiásMaria do Rosário Rodrigues Silva Email author 

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Abstract

In this study, we investigated the yeasts colonization of genus Candida, including C. dubliniensis, isolated of HIV-infected patients oral cavities and we accessed in vitro susceptibility pattern of the Candida isolates to four antifungal agents. Out of 99 patients investigated, 62 (62.6%) were colonized with yeasts. C. albicans was the prevailing species (50%). C. dubliniensis isolates were not recovered in our study. We verified that 8.1% of the yeasts isolated were resistant to fluconazole, 8.1% to itraconazole and 3.2% to voriconazole. The isolates demonstrated very low voriconazole MICs, in which 79% (49/62) presented values of 0.015 μg/ml. All Candida isolates were susceptible to amphotericin B. The results reported here showed that although C. albicans continues to be present in one-half of oral Candida carriage of HIV-infected patients, Candida non-albicans species are increasing among these patients. Besides, the findings of resistant isolates endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned.

Keywords

antifungal susceptibility asymptomatic oropharyngeal carriage Candida HIV-infected patients