, Volume 16, Issue 1, pp 7-47

State Space Realization of a Three-dimensional Image Set with Application to Noise Reduction of Fluorescent Microscopy Images of Cells

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Abstract

A method is presented to calculate state space realizations of a three-dimensional image set. It is based on interpreting the image set as the impulse response of a 3D separable system. As an application it is shown how this method, combined with approximation steps, including balanced model reduction, can be used to suppress noise in three-dimensional image sets. The approach was motivated by a practical problem in the analysis of three-dimensional fluorescent microscopy image data of fluorescently labelled cells. The method is illustrated by an analysis of simulated data and experimental data. The proposed approach can also be applied to a two-dimensional image in a straightforward way.

Received July 9, 2003; Revised April 20, 2003; Accepted June 11, 2004; First online version published in December 2004