Article

Molecular Biology Reports

, Volume 41, Issue 11, pp 7381-7386

First online:

Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene

  • Mustafa SolakAffiliated withDepartment of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University
  • , Mujgan Ozdemir ErdoganAffiliated withDepartment of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University Email author 
  • , Saliha Handan YildizAffiliated withDepartment of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University
  • , Kagan UcokAffiliated withDepartment of Physiology, Faculty of Medicine, Afyon Kocatepe University
  • , Seref YukselAffiliated withDepartment of Nephrology, Faculty of Medicine, Afyon Kocatepe University
  • , Evrim Suna Arıkan TerziAffiliated withDepartment of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University
  • , Ahmet BestepeAffiliated withFamily Health Center No: 2

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Abstract

The aim of this study is to investigate the genetic influence of polymorphisms in fat mass and obesity associated (FTO) gene on a sample of obese subjects and controls. Obesity is an epidemic all over the world. Several polymorphisms in the first intron of FTO gene have been associated with common forms of human obesity. In this research rs1421085 and rs9939609 polymorphisms of FTO gene were genotyped in 190 obese patients with a BMI ≥30 kg/m2 (Body Mass Index) and 97 healthy controls with a BMI of 18.5–24.9. Genotyping of SNPs was performed by real-time polymerase chain reaction. Body composition was established with bioelectric impedance analysis. Waist-to-hip ratio was determined for all participants. There were no significant differences (P > 0.05) between obese cases and controls in terms of genotype frequencies of rs1421085 and rs9939609 polymorphisms in our study. Also there were no significant correlations between genotypes and obesity related (anthropometric-body composition) parameters (P > 0.05).

Keywords

FTO Polymorphism Obesity BMI Body fat