Molecular Biology Reports

, Volume 41, Issue 7, pp 4389–4395

Immune-related chemotactic factors were found in acute coronary syndromes by bioinformatics

  • Lei Zhang
  • Jian Li
  • Aibin Liang
  • Yang Liu
  • Bing Deng
  • Hao Wang
Article

DOI: 10.1007/s11033-014-3310-7

Cite this article as:
Zhang, L., Li, J., Liang, A. et al. Mol Biol Rep (2014) 41: 4389. doi:10.1007/s11033-014-3310-7

Abstract

DNA microarray data for thrombus-related leukocyte from patients with acute coronary syndrome (ACS) was analyzed to acquire key genes associated with ACS. Microarray data set GSE19339, including four ACS patients’ samples and four normal samples, were downloaded from Gene Expression Omnibus database. Raw data was pre-processed and differentially expressed genes (DEGs) were identified by Affy packages of R. The interaction network was established with STRING. DrugBank was retrieved to obtain relevant small molecules. A total of 487 differentially expressed genes were identified as DEGs between normal and disease samples. Among which, ten up-regulated genes belonging to chemokine family (CCL2, CCR1, CXCL3, CXCL2, CCL8, CXCL11, CCL7, IL10, CCL22 and CCL20) were related to inflammatory response. In addition, two inhibitors of CCL2 (L-Mimosine) were retrieved from the DrugBank database. Considering the roles of inflammatory response in the progression of ACS and the functions of the ten up-regulated genes, we speculated that these genes might be related to ACS. Moreover, the inhibitors could provide guidelines for future drug design acting on these genes.

Keywords

Acute coronary syndromeDifferentially expressed geneFunctional enrichment analysisPathway analysisSmall molecule drug

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Lei Zhang
    • 1
  • Jian Li
    • 2
  • Aibin Liang
    • 3
  • Yang Liu
    • 4
  • Bing Deng
    • 5
  • Hao Wang
    • 1
  1. 1.Department of Special Needs Medical Branch, Shanghai Tongji Hospital, School of MedicineTongji UniversityShanghaiChina
  2. 2.Department of Geriatrics, Shanghai Tongji Hospital, School of MedicineTongji UniversityShanghaiChina
  3. 3.Department of Hematology, Shanghai Tongji Hospital, School of MedicineTongji UniversityShanghaiChina
  4. 4.Department of Cardiology, Shanghai Tongji Hospital, School of MedicineTongji UniversityShanghaiChina
  5. 5.Longhua Hospital Affiliated to Shanghai Traditional Chinese Medicine UniversityShanghaiChina