Molecular Biology Reports

, Volume 40, Issue 3, pp 2581–2587

Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis

  • Gwan Gyu Song
  • Sung Jae Choi
  • Jong Dae Ji
  • Young Ho Lee
Article

DOI: 10.1007/s11033-012-2344-y

Cite this article as:
Song, G.G., Choi, S.J., Ji, J.D. et al. Mol Biol Rep (2013) 40: 2581. doi:10.1007/s11033-012-2344-y

Abstract

The aim of this study was to determine whether the three functional interleukin-18 (IL-18) promoter −607 C/A (rs1946518), −137 G/C (rs187238), and −1297 C/T (rs360719) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. Meta-analysis was conducted on the associations between these IL-18 polymorphisms and SLE using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 11 comparisons (nine studies) involving 8,453 subjects (2,928 SLE patients and 5,525 controls) were included in the meta-analysis. In all study subjects, meta-analysis showed no association between SLE and the IL-18 −607 C allele (odds ratio [OR] = 1.065, 95 % confidence interval [CI] = 0.870–1.303, p = 0.541). However, stratification by ethnicity indicated a significant association between this allele and SLE in Europeans (OR = 0.864, 95 % CI = 0.757–0.986, p = 0.031), but not in Asians (OR = 1.230, 95 % CI = 0.902–1.676, p = 0.190). Meta-analyses showed the same pattern for the IL-18 −607 C allele using the dominant and additive models. Meta-analysis of the IL-18 −137 G/C polymorphism showed no association between SLE and the IL-18 −137 G allele in all study subjects (OR = 0.916, 95 % CI = 0.836–1.003, p = 0.057), but stratification by ethnicity indicated a significant association between this allele and SLE in Asians (OR = 0.792, 95 % CI = 0.629–0.997, p = 0.047), but not in Europeans (OR = 0.930, 95 % CI = 0.839–1.032, p = 0.171). Furthermore, meta-analysis showed that the IL-18 −1297 C allele was significantly associated with SLE in all study subjects and in Europeans (OR = 1.240, 95 % CI = 1.052–1.482, p = 0.010 and OR = 1.303, 95 % CI = 1.050–1.617, p = 0.016). This meta-analysis shows that the IL-18 −607 C/A and −1297 C/T polymorphism are associated with the development of SLE in Europeans, and the IL-18 −137 G/C polymorphism is associated with SLE in Asians.

Keywords

Interleukin-18PolymorphismSystemic lupus erythematosusMeta-analysis

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Gwan Gyu Song
    • 1
  • Sung Jae Choi
    • 1
  • Jong Dae Ji
    • 1
  • Young Ho Lee
    • 1
  1. 1.Division of Rheumatology, Department of Internal Medicine Korea University Anam HospitalKorea University College of MedicineSeoulKorea