Molecular Biology Reports

, Volume 40, Issue 2, pp 1591–1597

Two cases with hypereosinophilic syndrome shown with real-time PCR and responding well to imatinib treatment

  • Nur Selvi
  • Burçin Tezcanlı Kaymaz
  • Handan Haydaroğlu Şahin
  • Mustafa Pehlivan
  • Çağdaş Aktan
  • Ayşegül Dalmızrak
  • Ezgi İnalpolat
  • Buket Kosova
  • Mehmet Yılmaz
  • Vahap Okan
  • Güray Saydam
Article

DOI: 10.1007/s11033-012-2207-6

Cite this article as:
Selvi, N., Kaymaz, B.T., Şahin, H.H. et al. Mol Biol Rep (2013) 40: 1591. doi:10.1007/s11033-012-2207-6

Abstract

The aim of this work was to report two cases of hypereosinophilic syndrome (HES). FIP1L1-PDGFRA fusion was assessed with two protocols at RNA level. The fusion transcript was found positive at the RNA level with both PCR methods in two cases. In this study, the efficiency of imatinib treatment and a dramatic response in two HES cases with multisystemic involvement showing the characteristics of a chronic myeloproliferative disease were presented. Both cases showed complete responses confirming that imatinib mesylate treatment could be successful even in patients with advanced HES having myeloproliferative disease.

Keywords

HesImatinibReal-time PCRFIP1L1-PDGFRA fusion

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Nur Selvi
    • 1
  • Burçin Tezcanlı Kaymaz
    • 1
  • Handan Haydaroğlu Şahin
    • 2
  • Mustafa Pehlivan
    • 2
  • Çağdaş Aktan
    • 1
  • Ayşegül Dalmızrak
    • 1
  • Ezgi İnalpolat
    • 1
  • Buket Kosova
    • 1
  • Mehmet Yılmaz
    • 2
  • Vahap Okan
    • 2
  • Güray Saydam
    • 3
  1. 1.Department of Medical BiologySchool of Medicine, Ege UniversityIzmirTurkey
  2. 2.Department of HematologySchool of Medicine, Gaziantep UniversityGaziantepTurkey
  3. 3.Department of HematologySchool of Medicine, Ege UniversityIzmirTurkey