Article

Molecular Biology Reports

, Volume 40, Issue 1, pp 525-533

First online:

The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan

  • Chuan-Wei YangAffiliated withPh.D. Program for Aging, College of Medicine, China Medical UniversityDepartment of Medical Research, China Medical University Hospital
  • , Chia-Ing LiAffiliated withDepartment of Medical Research, China Medical University HospitalSchool of Medicine, College of Medicine, China Medical University
  • , Chiu-Shong LiuAffiliated withDepartment of Medical Research, China Medical University HospitalDepartment of Family Medicine, China Medical University HospitalSchool of Medicine, College of Medicine, China Medical University
  • , Da-Tian BauAffiliated withDepartment of Medical Research, China Medical University HospitalTerry Fox Cancer Research Laboratory, China Medical University & Hospital
  • , Chih-Hsueh LinAffiliated withDepartment of Family Medicine, China Medical University HospitalSchool of Medicine, College of Medicine, China Medical University
  • , Wen-Yuan LinAffiliated withDepartment of Family Medicine, China Medical University HospitalSchool of Medicine, College of Medicine, China Medical University
  • , Tsai-Chung LiAffiliated withGraduate Institute of Biostatistics, College of Public Health, China Medical UniversityDepartment of Healthcare Administration, College of Health Science, Asia University Email author 
  • , Cheng-Chieh LinAffiliated withPh.D. Program for Aging, College of Medicine, China Medical UniversityDepartment of Medical Research, China Medical University HospitalDepartment of Family Medicine, China Medical University HospitalSchool of Medicine, College of Medicine, China Medical University Email author 

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Abstract

Metabolic syndrome (MetS) is a combination of medical disorders, consisting of multiple, interrelated risk factors of metabolic origin. To investigate the associations of MetS with appetite-related genes (LEPR, near MC4R and SH2B1) and cholesterol metabolism-related gene (LRP5) polymorphism variants and the joint effect of cigarette smoking and these polymorphism variants on MetS in a community-based case–control study. Metabolic syndrome was defined according to the American Heart Association and National Heart Lung Blood Institute (AHA/NHLBI) criteria. A total of 237 MetS cases and 202 subjects without MetS aged 40 or over in Taiwan were analyzed. The genotypes of LRP5-rs3736228, LEPR-rs1137100, near MC4R-rs17782313 and SH2B1-rs4788102 were analyzed by the PCR–restriction fragment length polymorphism method. A strong association of the SNP rs17782313 near MC4R gene with MetS susceptibility was found. The data indicated that the C allele of near MC4R-rs17782313 is an obvious risk factor for MetS susceptibility. The joint effects of cigarette smoking and susceptible genotypes of LRP5, LEPR, near MC4R or SH2B1 genes led to a relatively higher risk of having MetS. Using subjects with the wild-type of LRP5, LEPR, near MC4R or SH2B1 genes and without a smoking habit as a reference group, those with cigarette smoking (current and former) and more than one variant type had a 4.1-fold (95 % CI = 1.6–10.2) risk of having MetS. The genotypes of the appetite-related genes (LEPR, near MC4R and SH2B1) and cholesterol metabolism-related gene (LRP5), together with a cigarette smoking habit, are important risk factors for MetS.

Keywords

Metabolic syndrome Cigarette smoking MC4R LRP5 SH2B1 Polymorphism