Molecular Biology Reports

, Volume 40, Issue 1, pp 255–262

Cervical cancer with polymorphism in MTHFR C677T gene: a systematic review and meta-analysis


DOI: 10.1007/s11033-012-2056-3

Cite this article as:
Xu, X., Zou, L. & Wang, D. Mol Biol Rep (2013) 40: 255. doi:10.1007/s11033-012-2056-3


To perform a meta-analysis investigating the association of MTHFR C677T polymorphism and susceptibility of cervical cancer. All case–control studies published in English and Chinese with estimates of the relationship between MTHFR C677T polymorphism and risk of cervical cancer were analyzed using odds ratio (OR) with 95 % confidence interval (CI). A total of 10 studies (2,023 cases and 2,570 controls) were included in the meta-analysis. No significant association was observed between T allele and C allele (OR = 0.90; 95 %CI = 0.70–1.17; P = 0.43), and for genotype TT versus CC (OR = 1.09; 95 %CI = 0.74–1.61; P = 0.67), CT versus CC (OR = 0.95; 95 %CI = 0.75–1.20; P = 0.65), CT + TT versus CC (OR = 0.91; 95 %CI = 0.66–1.24; P = 0.55). The current meta-analysis results suggest that the MTHFR C677T polymorphism may not be associated with cervical cancer.


MTHFR C677T Cervical cancer Polymorphism Meta-analysis 

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of Health InformaticsSchool of Health Services Management, Anhui Medical UniversityHefeiChina
  2. 2.Department of Occupational and Environmental HealthSchool of Public Health, Anhui Medical UniversityHefeiChina