Molecular Biology Reports

, Volume 39, Issue 12, pp 11073–11079

Association between SDF1-3′A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases

  • Ferruh K. İşman
  • Canan Kucukgergin
  • Selçuk Daşdemir
  • Bedia Cakmakoglu
  • Oner Sanli
  • Sule Seckin
Article

DOI: 10.1007/s11033-012-2010-4

Cite this article as:
İşman, F.K., Kucukgergin, C., Daşdemir, S. et al. Mol Biol Rep (2012) 39: 11073. doi:10.1007/s11033-012-2010-4

Abstract

In the present study, we aimed to investigate the association between SDF1-3′A and CXCR4 gene polymorphisms and the susceptibility and clinicopathological development of prostate cancer. SDF1-3′A and CXCR4 gene polymorphisms were assessed by polymerase chain reaction restriction-fragment length polymorphism (PCR–RFLP) in 149 healthy subjects and 152 patients with prostate cancer. There were no significant differences in the distributions of SDF-1 and CXCR4 genotypes between controls and prostate cancer patients. However, the patients with AA genotype of SDF1-3′A gene presented a higher risk for developing an advanced disease status as compared to patients with GG homozygotes (aOR = 2.02; 95 % CI = 1.05-3.90; P = 0.035). In addition, the distribution of AA genotype of SDF1-3′A gene was found significantly increased in the patients with bone metastasis in comparison to those without bone metastasis (aOR = 2.94; 95 % CI = 1.26-6.82; P = 0.012). On the other hand, CXCR4 gene polymorphism was not associated with the clinicopathological characteristics of prostate cancer. Our results suggest that SDF1-3′A and CXCR4 gene polymorphisms may not be risk factors for the susceptibility to prostate cancer. However, SDF1-3′A gene polymorphism may be associated with the progression and bone metastasis of prostate cancer in a Turkish men population.

Keywords

SDF-1(CXCL12) CXCR4 Single nucleotide polymorphism PCR–RFLP analysis Prostate cancer 

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Ferruh K. İşman
    • 1
  • Canan Kucukgergin
    • 2
  • Selçuk Daşdemir
    • 3
  • Bedia Cakmakoglu
    • 3
  • Oner Sanli
    • 4
  • Sule Seckin
    • 2
  1. 1.Clinical Biochemistry LaboratoryGoztepe Teaching and Research HospitalIstanbulTurkey
  2. 2.Department of Biochemistry, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  3. 3.Department of Molecular Medicine, Institute for Experimental Medicine ResearchIstanbul UniversityIstanbulTurkey
  4. 4.Department of Urology, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey

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