Molecular Biology Reports

, Volume 39, Issue 12, pp 10873–10879

HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case–control study

  • Flora Zagouri
  • Theodoros N. Sergentanis
  • Maria Gazouli
  • Alexandra Tsigginou
  • Constantine Dimitrakakis
  • Irene Papaspyrou
  • Evaggelos Eleutherakis-Papaiakovou
  • Dimosthenis Chrysikos
  • George Theodoropoulos
  • George C. Zografos
  • Aris Antsaklis
  • Athanassios-Meletios Dimopoulos
  • Christos A. Papadimitriou
Article

DOI: 10.1007/s11033-012-1984-2

Cite this article as:
Zagouri, F., Sergentanis, T.N., Gazouli, M. et al. Mol Biol Rep (2012) 39: 10873. doi:10.1007/s11033-012-1984-2

Abstract

This case control study aims to investigate the role of HSP90 Gln488His (C > G), HSP70-2 P1/P2, HIF-1 alpha C1772T and HSPA8 intronic 1541–1542delGT polymorphisms as potential risk factors and/or prognostic markers for breast cancer. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy cases were recruited. The above mentioned polymorphisms were genotyped; multivariate logistic regression was performed. HSP90 GG (His/His) genotype was associated with elevated breast cancer risk. Similarly, the allele dose–response model pointed to increase in breast cancer risk per G allele. HSP70-2 P1/P2, HSPA8 intronic 1541–1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose–response allele models. The positive association between HSP90 G allele and breast cancer risk seemed to pertain to both premenopausal and postmenopausal women. With respect to survival analysis, none of the aforementioned polymorphisms was associated with either disease-free survival or overall survival. HSP90α Gln488His polymorphism seems to be a risk factor for breast cancer. On the other hand, our study did not point to excess risk conferred by HSPA8 1541–1542delGT, Hsp70-2 P1/P2 and HIF-1α C1772T.

Keywords

PolymorphismBreast cancerHSP90Case–control

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Flora Zagouri
    • 1
  • Theodoros N. Sergentanis
    • 2
  • Maria Gazouli
    • 3
  • Alexandra Tsigginou
    • 4
  • Constantine Dimitrakakis
    • 4
  • Irene Papaspyrou
    • 1
  • Evaggelos Eleutherakis-Papaiakovou
    • 1
  • Dimosthenis Chrysikos
    • 2
  • George Theodoropoulos
    • 2
  • George C. Zografos
    • 2
  • Aris Antsaklis
    • 4
  • Athanassios-Meletios Dimopoulos
    • 1
  • Christos A. Papadimitriou
    • 1
  1. 1.Department of Clinical Therapeutics, Alexandra HospitalUniversity of AthensAthensGreece
  2. 2.1st Propaedeutic Surgical Department, Hippocrateio HospitalUniversity of AthensAthensGreece
  3. 3.Department of BiologyUniversity of AthensAthensGreece
  4. 4.Department of Obstetrics and Gynaecology Alexandra HospitalUniversity of AthensAthensGreece