Molecular Biology Reports

, Volume 39, Issue 6, pp 6933–6942

ERCC1 expression as a prognostic and predictive factor in patients with non-small cell lung cancer: a meta-analysis

  • Jingwei Jiang
  • Xiaohua Liang
  • Xinli Zhou
  • Ruofan Huang
  • Zhaohui Chu
  • Qiong Zhan
Article

DOI: 10.1007/s11033-012-1520-4

Cite this article as:
Jiang, J., Liang, X., Zhou, X. et al. Mol Biol Rep (2012) 39: 6933. doi:10.1007/s11033-012-1520-4
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Abstract

It is hypothesized that high expression of the excision repair cross-complementation group 1 (ERCC1) gene might be a positive prognostic factor, but predict decreased sensitivity to platinum-based chemotherapy. Results from the published data are inconsistent. To derive a more precise estimation of the relationship between ERCC1 and the prognosis and predictive response to chemotherapy of non-small cell lung cancer (NSCLC), a meta-analysis was performed. An electronic search of the PubMed and Embase database was performed. Hazard ratio (HR) for overall survival (OS) was pooled in early stage patients received surgery alone to analyze the prognosis of ERCC1 on NSCLC. HRs for OS in patients received surgery plus adjuvant chemotherapy and in patients received palliative chemotherapy and relative risk (RR) for overall response to chemotherapy were aggregated to analyze the prediction of ERCC1 on NSCLC. The pooled HR indicated that high ERCC1 levels were associated with longer survival in early stage patients received surgery alone (HR, 0.69; 95% confidence interval (CI), 0.58–0.83; P = 0.000). There was no difference in survival between high and low ERCC1 levels in patients received surgery plus adjuvant chemotherapy (HR, 1.41; 95% CI, 0.93–2.12; P = 0.106). However, high ERCC1 levels were associated with shorter survival and lower response to chemotherapy in advanced NSCLC patients received palliative chemotherapy (HR, 1.75; 95% CI, 1.39–2.22; P = 0.000; RR, 0.77; 95% CI, 0.64–0.93; P = 0.007; respectively). The meta-analysis indicated that high ERCC1 expression might be a favourable prognostic and a drug resistance predictive factor for NSCLC.

Keywords

Carcinoma, non-small cell lung Excision repair cross-complementation group 1 DNA-binding proteins Drug resistance Neoplasm Meta-analysis 

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Jingwei Jiang
    • 1
    • 2
  • Xiaohua Liang
    • 1
    • 2
  • Xinli Zhou
    • 1
    • 2
  • Ruofan Huang
    • 1
    • 2
  • Zhaohui Chu
    • 1
    • 2
  • Qiong Zhan
    • 1
    • 2
  1. 1.Department of Oncology, Huashan HospitalFudan UniversityShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina

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