Molecular Biology Reports

, Volume 39, Issue 3, pp 2243–2252

MicroRNAs in brain development and degeneration

  • Ana-Maria Enciu
  • Bogdan Ovidiu Popescu
  • Ancuta Gheorghisan-Galateanu
Article

DOI: 10.1007/s11033-011-0973-1

Cite this article as:
Enciu, AM., Popescu, B.O. & Gheorghisan-Galateanu, A. Mol Biol Rep (2012) 39: 2243. doi:10.1007/s11033-011-0973-1
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Abstract

microRNAs are short, non-coding RNAs, that exert a posttranscriptional control on protein synthesis by mRNA interference. They are involved in normal and pathological embryologic development, as well as in adult life pathology, from myocardial infarction to cancer. There are several brain-specific species of microRNA, showing time-dependent pattern of expression, selectivity for neuronal population, significant roles in correct cellular differentiation and system development. The growing interest in microRNAs extended also in the area of neurodegeneration, some of brain-restricted microRNAs being reported to associate with disorders such as Alzheimer’s disease, Parkinson’s disease or Huntington’s disease. The microRNAs research in the last 3 years offered a considerable amount of information that needs to be integrated in the vast machinery of cellular biology.

Keywords

MicroRNA Brain development Neurodegeneration Alzheimer’s disease 

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Ana-Maria Enciu
    • 1
  • Bogdan Ovidiu Popescu
    • 1
    • 2
    • 3
  • Ancuta Gheorghisan-Galateanu
    • 1
    • 4
  1. 1.Department of Cellular and Molecular Medicine, School of Medicine‘Carol Davila’ University of Medicine and PharmacyBucharestRomania
  2. 2.Laboratory of Molecular Medicine‘Victor Babeş’ National Institute of PathologyBucharestRomania
  3. 3.Department of NeurologyUniversity Hospital Bucharest, ‘Carol Davila’ University of Medicine and PharmacyBucharestRomania
  4. 4.BucharestRomania

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