Molecular Biology Reports

, Volume 39, Issue 2, pp 2039–2044

CXCL12 G801A polymorphism and breast cancer risk: a meta-analysis


DOI: 10.1007/s11033-011-0951-7

Cite this article as:
Shen, W., Cao, X., Xi, L. et al. Mol Biol Rep (2012) 39: 2039. doi:10.1007/s11033-011-0951-7


The G801A polymorphism in the CXCL12 gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively. Five published case–control studies, including 1,058 breast cancer cases and 1,023 controls were identified. No study had a deviation from the Hardy–Weinberg equilibrium (HWE) in controls. We found that the CXCL12 G801A (rs1801157) polymorphism was associated with a significantly increased risk of breast cancer risk when all studies were pooled into the meta-analysis (codomiant model: AA versus GG, OR = 1.64, 95% CI = 1.16–2.33; GA versus GG, OR = 1.42, 95% CI = 1.18–1.71; dominant model: AA/GA versus GG, OR = 1.44, 95% CI = 1.21–1.72). Furthermore, Egger’s test did not show any evidence of publication bias (P > 0.05 for the dominant model). In conclusion, the results suggest that the CXCL12 G801A polymorphism may be a low-penetrant risk factor for developing breast cancer.


CXCL12Breast cancerMeta-analysisMolecular epidemiology

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Weisheng Shen
    • 1
  • Xiangming Cao
    • 1
  • Lei Xi
    • 1
  • Lichun Deng
    • 1
  1. 1.Department of OncologyThe Affiliated Jiangyin Hospital of Southeast University Medical CollegeWuxiPeople’s Republic of China