Molecular Biology Reports

, Volume 39, Issue 2, pp 1809–1813

Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease

Article

DOI: 10.1007/s11033-011-0922-z

Cite this article as:
Li, Y., Tang, K., Zhou, K. et al. Mol Biol Rep (2012) 39: 1809. doi:10.1007/s11033-011-0922-z

Abstract

In the past decade, a number of case-control studies have been conducted to investigate the relationship between the ATP-binding cassette transporter A1 (ABCA1) R219K polymorphism and coronary heart disease (CHD). However, the results have been inconclusive. The purpose of the present study is to investigate whether this polymorphism confers significant susceptibility to CHD using a meta-analysis. PubMed, Embase and CNKI database were searched to get the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed. In total, 9,437 cases and 16,270 controls were involved in the meta-analysis. The K219 was significantly associated with CHD (OR = 0.80, 95% CI 0.69–0.92, P(Z) = 0.001). However, significant heterogeneity was present. Further subgroup analysis suggested ethnicity explained much heterogeneity. In Asians, K219 showed a strong protective effect and the pooled OR was 0.69 (95% CI 0.55–0.86 P(Z) = 0.0009). While in Caucasians the result was not significant (OR = 0.87, 95% CI 0.73–1.04, P(Z) = 0.12). In conclusion, our results indicate that the ABCA1 R219K polymorphism is a protective factor of CHD in Asians, but not in Caucasians.

Keywords

Meta-analysis Coronary heart disease ATP-binding cassette transporter A1 Genetic polymorphism 

Supplementary material

11033_2011_922_MOESM1_ESM.doc (96 kb)
Supplementary material 1 (DOC 95 kb)
11033_2011_922_MOESM2_ESM.doc (50 kb)
Supplementary material 2 (DOC 49 kb)

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education)Shanghai Jiao Tong UniversityShanghaiChina
  2. 2.Institutes for Nutritional Sciences, Shanghai Institute of Biological SciencesChinese Academy of SciencesShanghaiChina
  3. 3.Institutes of Biomedical SciencesFudan UniversityShanghaiChina

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