Article

Molecular Biology Reports

, Volume 38, Issue 8, pp 5125-5132

First online:

CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with −318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients

  • Shaoqiong DuanAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
  • , Guoyu ZhangAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
  • , Qunying HanAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
  • , Zhu LiAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
  • , Zhengwen LiuAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University Email author 
  • , Jinghong ChenAffiliated withKey Laboratory of Environment and Genes related to Diseases, Ministry of Education, Institute of Endemic Diseases, School of Medicine, Xi’an Jiaotong University
  • , Yi LvAffiliated withDepartment of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
  • , Na LiAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
  • , Yawen WangAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
    • , Man LiAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
    • , Sai LouAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
    • , Mingbo YangAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
    • , Qianqian ZhuAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
    • , Fanfan XingAffiliated withDepartment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University

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Abstract

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) plays a pivotal role in regulating T cell activation, which is believably critical for the outcome of hepatitis B virus (HBV) infection. The expression and function of CTLA-4 may be affected by gene polymorphisms. This study investigated the influence of CTLA-4 polymorphisms on disease susceptibility in Chinese Han patients with chronic HBV infection. CTLA-4 +49A/G and −318C/T polymorphisms were evaluated by DNA amplification with polymerase chain reaction followed by the restriction fragment length polymorphism analysis. The patients with chronic HBV infection had higher frequencies of genotype AA and allele A of CTLA-4 +49A/G polymorphism. The haplotype +49A−318C was significantly over-represented (P < 0.001) and haplotype +49G−318C under-represented (P = 0.006) in the patients. The +49GG genotype was more frequent (P = 0.009) and +49A allele was less frequent in patients with lower ALT levels (P = 0.012) in HBeAg positive chronic hepatitis B. It is indicated that CTLA-4 +49A/G polymorphism alone and in a haplotype with −318C allele may confer susceptibility to chronic HBV infection in Chinese Han patients.

Keywords

Chronic HBV infection CTLA-4 Genetic polymorphism Association