Molecular Biology Reports

, Volume 38, Issue 8, pp 4847–4853

TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis

  • Jing-Jun Wang
  • Yuan Zheng
  • Liang Sun
  • Li Wang
  • Peng-Bo Yu
  • Jian-Hua Dong
  • Lei Zhang
  • Jing Xu
  • Wei Shi
  • Yu-Chun Ren
Article

DOI: 10.1007/s11033-010-0619-8

Cite this article as:
Wang, JJ., Zheng, Y., Sun, L. et al. Mol Biol Rep (2011) 38: 4847. doi:10.1007/s11033-010-0619-8

Abstract

Colorectal cancer constitutes a significant proportion of the global burden of cancer morbidity and mortality. A number of studies have been conducted to explore whether TP53 codon 72 polymorphism is associated with colorectal cancer susceptibility. However, controversial results were obtained. In order to derive a more precise estimation of the relationship, we systematically searched Medline, Google scholar, and Ovid database for studies reported before May 2010. A total of 3603 colorectal cancer cases and 5524 controls were included. TP53 codon 72 polymorphism was not associated with colorectal cancer risk in all genetic models (for dominant model: OR = 0.99, 95% CI: 0.86–1.15; for recessive model: OR = 1.00, 95% CI: 0.81–1.23; for Arg/Pro vs. Arg/Arg: OR = 1.00, 95% CI: 0.87–1.15; for Pro/Pro vs. Arg/Arg: OR = 0.97, 95% CI: 0.76–1.25). In the subgroup analyses by ethnic groups and sources of controls, no significant associations were found in all models. Taken together, this meta-analysis suggested that the biologically usefulness of TP53 codon 72 polymorphism as a selection marker in colorectal cancer susceptibility may be very limited.

Keywords

TP53Codon 72Colorectal cancerMeta-analysis

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Jing-Jun Wang
    • 1
  • Yuan Zheng
    • 1
  • Liang Sun
    • 2
  • Li Wang
    • 1
  • Peng-Bo Yu
    • 1
  • Jian-Hua Dong
    • 1
  • Lei Zhang
    • 1
  • Jing Xu
    • 1
  • Wei Shi
    • 1
  • Yu-Chun Ren
    • 1
  1. 1.Department of Center for Disease Control and Prevention of Shaanxi ProvinceXi’anPeople’s Republic of China
  2. 2.Department of Center for Disease Control and Prevention of FuyangFuyangChina