Article

Molecular Biology Reports

, Volume 38, Issue 8, pp 4847-4853

First online:

TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis

  • Jing-Jun WangAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
  • , Yuan ZhengAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province Email author 
  • , Liang SunAffiliated withDepartment of Center for Disease Control and Prevention of Fuyang
  • , Li WangAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
  • , Peng-Bo YuAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
  • , Jian-Hua DongAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
  • , Lei ZhangAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
  • , Jing XuAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
  • , Wei ShiAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province
    • , Yu-Chun RenAffiliated withDepartment of Center for Disease Control and Prevention of Shaanxi Province

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Abstract

Colorectal cancer constitutes a significant proportion of the global burden of cancer morbidity and mortality. A number of studies have been conducted to explore whether TP53 codon 72 polymorphism is associated with colorectal cancer susceptibility. However, controversial results were obtained. In order to derive a more precise estimation of the relationship, we systematically searched Medline, Google scholar, and Ovid database for studies reported before May 2010. A total of 3603 colorectal cancer cases and 5524 controls were included. TP53 codon 72 polymorphism was not associated with colorectal cancer risk in all genetic models (for dominant model: OR = 0.99, 95% CI: 0.86–1.15; for recessive model: OR = 1.00, 95% CI: 0.81–1.23; for Arg/Pro vs. Arg/Arg: OR = 1.00, 95% CI: 0.87–1.15; for Pro/Pro vs. Arg/Arg: OR = 0.97, 95% CI: 0.76–1.25). In the subgroup analyses by ethnic groups and sources of controls, no significant associations were found in all models. Taken together, this meta-analysis suggested that the biologically usefulness of TP53 codon 72 polymorphism as a selection marker in colorectal cancer susceptibility may be very limited.

Keywords

TP53 Codon 72 Colorectal cancer Meta-analysis