Molecular Biology Reports

, Volume 38, Issue 4, pp 2517–2528

β-Arrestins: multifunctional signaling adaptors in type 2 diabetes

Authors

  • Xiaotao Feng
    • Institute of Chinese Integrative Medicine, Huashan HospitalFudan University
    • Institute of Chinese Integrative Medicine, Huashan HospitalFudan University
    • Institute of Integrated Medicine in Clinic, Shanghai Academy of Traditional Chinese Medicine, Yueyang Integrative Medicine HospitalShanghai Traditional Chinese Medicine University
  • Jibo Liu
    • Institute of Chinese Integrative Medicine, Huashan HospitalFudan University
    • Institute of Chinese Integrative Medicine, Huashan HospitalFudan University
Article

DOI: 10.1007/s11033-010-0389-3

Cite this article as:
Feng, X., Wang, W., Liu, J. et al. Mol Biol Rep (2011) 38: 2517. doi:10.1007/s11033-010-0389-3

Abstract

β-Arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While β-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for β-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.

Keywords

β-Arrestin Signal transduction Insulin resistance Lipotoxicity Type 2 diabetes

Copyright information

© Springer Science+Business Media B.V. 2010