β-Arrestins: multifunctional signaling adaptors in type 2 diabetes
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- Feng, X., Wang, W., Liu, J. et al. Mol Biol Rep (2011) 38: 2517. doi:10.1007/s11033-010-0389-3
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β-Arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While β-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for β-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.