Molecular Biology Reports

, Volume 38, Issue 3, pp 1733–1739

Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population

  • Hitender Thakur
  • Lipsy Gupta
  • Ranbir C. Sobti
  • Ashok K. Janmeja
  • Amlesh Seth
  • Sharwan K. Singh
Article

DOI: 10.1007/s11033-010-0287-8

Cite this article as:
Thakur, H., Gupta, L., Sobti, R.C. et al. Mol Biol Rep (2011) 38: 1733. doi:10.1007/s11033-010-0287-8

Abstract

The glutathione S-transferase (GST) family of enzymes is known to play a pivotal role in phase II of biotransformation of xenobiotics, environmental carcinogens and pharmacological drugs. The objective of the present study was to investigate the role of GSTM1 and GSTT1 null genotypes as risk factors for chronic obstructive pulmonary disease (COPD) and prostate cancer. The subjects appraised were 200 COPD cases, 150 prostate cancer cases, 150 benign prostatic hyperplasia (BPH) cases, 200 age matched controls for COPD and 172 age matched controls for prostate cancer. GSTM1 and GSTT1 null genotype was found to confer 2.5 (OR 2.45; 95% CI 1.56–3.82; P value = 0.00008) and 2.4-fold (OR 2.39; 95% CI 1.36–4.20; P value = 0.002) significant higher risk for prostate cancer. Smoking imparted a 2.2-fold significant risk of prostate cancer cases (OR 2.23; 95% CI 1.36–3.65 P value = 0.001) and twofold risk in BPH (OR 2.09; 95% CI 1.26–3.46; P value = 0.005). In case of COPD only null genotype of GSTT1 has shown 2.1-fold (OR 2.11; 95% CI 1.22–3.62; P value = 0.007) significant increased risk.

Keywords

Prostate cancerCOPDGlutathione S-transferase M1 (GSTM1)Glutathione S-transferase T1 (GSTT1)Polymorphism

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Hitender Thakur
    • 1
  • Lipsy Gupta
    • 1
  • Ranbir C. Sobti
    • 1
  • Ashok K. Janmeja
    • 2
  • Amlesh Seth
    • 3
  • Sharwan K. Singh
    • 4
  1. 1.Department of BiotechnologyPanjab UniversityChandigarhIndia
  2. 2.Department of Pulmonary MedicineGovt Medical College and HospitalChandigarhIndia
  3. 3.Department of UrologyAll India Institute of Medical SciencesNew DelhiIndia
  4. 4.Department of UrologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia