Article

Molecular Biology Reports

, Volume 38, Issue 2, pp 1263-1267

First online:

CCL2 −2518 A/G single nucleotide polymorphism as a risk factor for breast cancer

  • Łukasz KruszynaAffiliated withDepartment of Biochemistry and Molecular Biology, Poznań University of Medical Sciences
  • , Margarita LianeriAffiliated withDepartment of Biochemistry and Molecular Biology, Poznań University of Medical Sciences
  • , Błażej RubisAffiliated withDepartment of Biochemistry and Molecular Biology, Poznań University of Medical SciencesDepartment of Clinical Chemistry and Molecular Diagnostics, Poznań University of Medical Sciences
  • , Hanna KnułaAffiliated withDepartment of Clinical Chemistry and Molecular Diagnostics, Poznań University of Medical Sciences
  • , Maria RybczyńskaAffiliated withDepartment of Clinical Chemistry and Molecular Diagnostics, Poznań University of Medical Sciences
  • , Sylwia Grodecka-GazdeckaAffiliated withDepartment of Oncological Surgery, Department of Oncology, Poznań University of Medical Sciences
  • , Paweł P. JagodzińskiAffiliated withDepartment of Biochemistry and Molecular Biology, Poznań University of Medical Sciences Email author 

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Abstract

The contribution of the CCL2 −2518 A>G (rs 1024611) polymorphism in the occurrence and progression of various cancers has been found to be discordant. We studied the prevalence of the CCL2 −2518 A>G polymorphism in patients with breast cancer (n = 160) and controls (n = 323) in a sample of the Polish population. There were no significant differences in CCL2 −2518 A>G genotypes between patients with breast tumors and controls. Odds ratio (OR) for patients bearing the GG genotype was 1.481 (95% CI = 0.7711–2.845, P = 0.2358), and OR of the GG and AG genotypes was 0.7269 (95% CI = 0.4967–1.064, P = 0.1002). There was also no significant distinction in the prevalence of alleles between patients and healthy individuals. OR for the CCL2 −2518 G allele frequency was 0.8903 (95% CI = 0.6611–1.199, P = 0.4441). Analysis of the association between tumor size, lymph node metastases, histological grade, and distribution of genotypes and alleles for the CCL2 −2518 A>G polymorphism also did not show significant differences. Our results did not show association of the CCL2 −2518 A>G polymorphism with breast cancer occurrence and clinical characteristics in a sample of the Polish cohort.

Keywords

CCL2 Breast cancer Polymorphism