Molecular Biology Reports

, Volume 38, Issue 2, pp 1145–1150

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

  • Zhen Yang
  • Jie Wen
  • Xiaoming Tao
  • Bin Lu
  • Yanping Du
  • Mei Wang
  • Xuanchun Wang
  • Weiwei Zhang
  • Wei Gong
  • Charlotte Ling
  • Songhua Wu
  • Renming Hu
Article

DOI: 10.1007/s11033-010-0212-1

Cite this article as:
Yang, Z., Wen, J., Tao, X. et al. Mol Biol Rep (2011) 38: 1145. doi:10.1007/s11033-010-0212-1

Abstract

Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case–control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis I°, 90 with steatosis hepatis II° and 28 with steatosis hepatis III°) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139–2.271, P[dom] = 7.2 × 10−3). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P[add] = 3.8 × 10−4) and CRP (P[add] = 2.9 × 10−4) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.

Keywords

GCKRPolymorphismNon-alcoholic fatty liver diseaseCRPTriglyceride

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Zhen Yang
    • 1
  • Jie Wen
    • 1
  • Xiaoming Tao
    • 1
  • Bin Lu
    • 1
  • Yanping Du
    • 1
  • Mei Wang
    • 1
  • Xuanchun Wang
    • 1
  • Weiwei Zhang
    • 1
  • Wei Gong
    • 1
  • Charlotte Ling
    • 2
  • Songhua Wu
    • 3
  • Renming Hu
    • 1
  1. 1.Department of Endocrinology and Metabolism, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical SchoolFudan UniversityShanghaiChina
  2. 2.Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, CRC Malmö University HospitalLund University Diabetes CenterMalmöSweden
  3. 3.Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai No. 6 People HospitalShanghai Jiaotong UniversityShanghaiChina