Article

Molecular Biology Reports

, Volume 37, Issue 3, pp 1611-1618

First online:

Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene

  • Zhisheng ZhangAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Delin MoAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Peiqing CongAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Zuyong HeAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Fei LingAffiliated withSchool of Bioscience and Bioengineering, South China University of Technology
  • , Anning LiAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Yuna NiuAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Xiao ZhaoAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
  • , Chunyan ZhouAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
    • , Yaosheng ChenAffiliated withState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University Email author 

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Abstract

The product of transmembrane and coiled-coil domains 1 (TMCO1) gene is a member of DUF841 superfamily of several eukaryotic proteins with unknown function. The partial DNA sequence of porcine TMCO1 was first cloned with a pig 567 bp ORF encoding 188 amino acids. By tissues expression analysis, the TMCO1 was found highly expressed in the liver, kidney and heart. The porcine TMCO1 protein was subsequently demonstrated to localize in the mitochondrion by confocal fluorescence microscopy. This data provides an important basis for conducing further studies on the functions and regulatory mechanisms underlying the role of TMCO1 gene.

Keywords

Pig TMCO1 Expression pattern Subcellular localization