Molecular Biology Reports

, Volume 37, Issue 3, pp 1513–1522

The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

  • Jun-jing Jia
  • Yun-bo Tian
  • Zhen-hui Cao
  • Lin-li Tao
  • Xi Zhang
  • Si-zhen Gao
  • Chang-rong Ge
  • Qiu-Ye Lin
  • M. Jois
Article

DOI: 10.1007/s11033-009-9550-2

Cite this article as:
Jia, J., Tian, Y., Cao, Z. et al. Mol Biol Rep (2010) 37: 1513. doi:10.1007/s11033-009-9550-2

Abstract

Uncoupling protein 1 (UCP1), a 32-kDa protein located in the inner mitochondrial membrane, is abundant in brown adipose tissue, as a proton transporter in mitochondria inner membrane which uncouples oxidative metabolism from ATP synthesis and dissipates energy through the heat. UCP1 has been reported to play important roles for energy homeostasis in rodents and neonate of larger mammals including human. Recently, numerous candidate genes were searched to determine the genetic factors implicated in the pathogenesis of obesity, related metabolic disorders and diabetes. UCP-1, which plays a major role in thermogenesis, was suggested to be one of the candidates. This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans, and the genetic variety association with the fat metabolism, obesity and diabetes.

Keywords

UCP1 Polymorphism BAT Obesity Diabetes 

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Jun-jing Jia
    • 1
  • Yun-bo Tian
    • 2
  • Zhen-hui Cao
    • 1
  • Lin-li Tao
    • 1
  • Xi Zhang
    • 1
  • Si-zhen Gao
    • 1
  • Chang-rong Ge
    • 1
  • Qiu-Ye Lin
    • 1
  • M. Jois
    • 3
  1. 1.Yunnan Provincial Laboratory of Animal Nutrition and Feed ScienceYunnan Agricultural UniversityKunmingPeople’s Republic of China
  2. 2.College of ZhongKai Agricultural Technology and ScienceGuangzhouPeople’s Republic of China
  3. 3.Department of Agriculture, School of Life SciencesLa Trobe UniversityBundooraAustralia