Article

Molecular Biology Reports

, Volume 37, Issue 3, pp 1467-1475

First online:

Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia

  • Xiangqian HouAffiliated withDepartment of Vascular Surgery, Shandong Provincial Hospital, Shandong University
  • , Xuejun WuAffiliated withDepartment of Vascular Surgery, Shandong Provincial Hospital, Shandong University
  • , Junxi MaAffiliated withDepartment of Vascular Surgery, Shandong Provincial Hospital, Shandong University
  • , Xinhui LvAffiliated withDepartment of Vascular Surgery, Shandong Provincial Hospital, Shandong University
  • , Xing JinAffiliated withDepartment of Vascular Surgery, Shandong Provincial Hospital, Shandong University Email author 

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Abstract

Transplantation of adult marrow stromal cells (MSCs) has been developed as a new method of treating severe ischemia diseases by therapeutic angiogenesis. Erythropoietin (EPO) is capable of inducing angiogenesis and inhibiting MSCs apoptosis. The effect of EPO on the therapeutic potency of MSCs transplantation in a rat model of limb ischemia was investigated in the current study. The results indicate that the combined treatment with MSC transplantation and EPO infusion is superior to MSC transplantation alone in the treatment of limb ischemia. MSCs transplantation and EPO infusion could enhance the angiogenic effect of each other to achieve a better therapeutic effect. This combination therapy may become a more effective approach for ischemia diseases of the limbs.

Keywords

Erythropoietin Marrow stromal cells Limb ischemia