Molecular Biology Reports

, 36:2259

Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle

Authors

  • Bao Zhang
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
    • Institute of Cellular and Molecular BiologyXuzhou Normal University
  • Yikun Guo
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
  • Liangzhi Zhang
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
  • Miao Zhao
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
  • Xianyong Lan
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
  • Chunlei Zhang
    • Institute of Cellular and Molecular BiologyXuzhou Normal University
  • Chuanying Pan
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
  • Shenrong Hu
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
  • Juqiang Wang
    • Research Center of Cattle Engineering Technology in Henan
  • Chuzhao Lei
    • College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F University
Article

DOI: 10.1007/s11033-008-9442-x

Cite this article as:
Zhang, B., Chen, H., Guo, Y. et al. Mol Biol Rep (2009) 36: 2259. doi:10.1007/s11033-008-9442-x

Abstract

GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Associations between the GHSR gene polymorphism and the growth traits were revealed in Nanyang cattle. The mutations at nt456(G > A) and nt667(C > T) were complete linkage and located in exon 1 of the coding region of the GHSR gene. Least squares analysis revealed a significant statistical effect (P < 0.05) of the GHSR gene different genotypes on body weight and average daily gain at 6 months of age in Nanyang cattle. Individuals with GHSR-MM genotype showed higher body weight and average daily gain than individuals with GHSR-MN genotype.

Keywords

Cattle GHSR gene Polymorphism SNP (single nucleotide polymorphism) Growth traits

Copyright information

© Springer Science+Business Media B.V. 2009