Molecular Biology Reports

, Volume 36, Issue 3, pp 495–499

Association of MDR1 C3435T polymorphism with bipolar disorder in patients treated with valproic acid

  • Gunfer Turgut
  • Erhan Kurt
  • Cem Sengul
  • Gazi Alatas
  • Raziye Kursunluoglu
  • Timucin Oral
  • Sabahat Turgut
  • Hasan Herken
Article

DOI: 10.1007/s11033-007-9206-z

Cite this article as:
Turgut, G., Kurt, E., Sengul, C. et al. Mol Biol Rep (2009) 36: 495. doi:10.1007/s11033-007-9206-z

Abstract

P-glycoprotein (P-gp), an efflux transporter protein, is an ABC transporter encoded by the multidrug resistance 1 gene (MDR1, ABCB1). The common synonymous C3435T polymorphism in exon 26 is reported to associate with lower P-gp functional expression and drug uptake. Many extended pharmacogenomics, functional, and complex disease association studies focused mainly on this polymorphism. We investigated the association of exon 26 C3435T genetic variants of MDR1 gene with susceptibility to bipolar disorder and serum valproic acid concentration. Totally, 104 patients meeting DSM-IV criteria for bipolar disorder and 169 controls were admitted to the study. There was statistically significant difference between the genotypes of bipolar patients (CT 91.2%, TT 6.8%, and CC 2%) and controls (CT 52.7%, TT 26%, CC 21.3%) although their allelic distribution was similar. The serum valproic acid concentrations of the patients with CT, TT and CC genotypes were 72.92 ± 20.55, 80.47 ± 14.01 and 68.29 ± 12.17 μg/ml, respectively, and there was no significant difference between the C3435T genotypes.

Keywords

MDR1Bipolar disorderValproic acidGenetic polymorphism

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Gunfer Turgut
    • 1
  • Erhan Kurt
    • 2
  • Cem Sengul
    • 3
    • 4
  • Gazi Alatas
    • 2
  • Raziye Kursunluoglu
    • 1
  • Timucin Oral
    • 2
  • Sabahat Turgut
    • 1
  • Hasan Herken
    • 3
  1. 1.Department of PhysiologyPamukkale UniversityDenizliTurkey
  2. 2.Bakırköy Mental and Psychological Health HospitalIstanbulTurkey
  3. 3.Department of PsychiatryPamukkale UniversityDenizliTurkey
  4. 4.Tıp Fakultesi HastanesiPamukkale UniversitesiDenizliTurkey