Molecular Biology Reports

, 35:163

Strand compositional asymmetries in vertebrate large genes

Authors

  • Hai-Fang Wang
    • Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life SciencesBeijing Normal University
  • Wen-Ru Hou
    • Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life SciencesBeijing Normal University
    • National Institute of Biological Sciences
    • Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life SciencesBeijing Normal University
Article

DOI: 10.1007/s11033-007-9066-6

Cite this article as:
Wang, H., Hou, W. & Niu, D. Mol Biol Rep (2008) 35: 163. doi:10.1007/s11033-007-9066-6

Abstract

Both transcription-associated and replication-associated strand compositional asymmetries have recently been shown in vertebrate genomes. In this paper, we illustrate that transcription-associated strand compositional asymmetries and replication-associated ones coexist in most vertebrate large genes, although in most case the former conceals the latter. Furthermore, we found that the transcription-associated strand compositional asymmetries of housekeeping genes are stronger than those of somatic cell expressed genes. Together with other evidence, we suggest that germline transcription-associated strand asymmetric mutations may be the main cause of the transcription-associated strand compositional asymmetries.

Keywords

Cumulative skew diagramIllegitimate transcriptionReplicationTranscription

Abbreviations

CSD

Cumulative skew diagram

CSDD

Cumulative skew difference diagram

Supplementary material

11033_2007_9066_MOESM1_ESM.pdf (635 kb)
ESM1 (PDF 635 kb)
11033_2007_9066_MOESM2_ESM.pdf (297 kb)
ESM3 (PDF 297 kb)
11033_2007_9066_MOESM3_ESM.pdf (553 kb)
ESM1 (PDF 553 kb)

Copyright information

© Springer Science+Business Media, Inc. 2007