Strand compositional asymmetries in vertebrate large genes
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- Wang, H., Hou, W. & Niu, D. Mol Biol Rep (2008) 35: 163. doi:10.1007/s11033-007-9066-6
Both transcription-associated and replication-associated strand compositional asymmetries have recently been shown in vertebrate genomes. In this paper, we illustrate that transcription-associated strand compositional asymmetries and replication-associated ones coexist in most vertebrate large genes, although in most case the former conceals the latter. Furthermore, we found that the transcription-associated strand compositional asymmetries of housekeeping genes are stronger than those of somatic cell expressed genes. Together with other evidence, we suggest that germline transcription-associated strand asymmetric mutations may be the main cause of the transcription-associated strand compositional asymmetries.
KeywordsCumulative skew diagramIllegitimate transcriptionReplicationTranscription
Cumulative skew diagram
Cumulative skew difference diagram