, Volume 18, Issue 2, pp 295-306
Date: 18 Feb 2014

Evaluation of the thiazole Schiff bases as \(\upbeta \) -glucuronidase inhibitors and their in silico studies

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Twenty eight (28) derivatives 229 were synthesized and four analogs were found to exhibit single-digit \(\hbox {IC}_{50}\) values as \(\upbeta \) -glucuronidase inhibitors. Molecular modeling indicates that three factors: substituent R, lone pair on the nitrogen of azomethine part, and the interactions made by the main skeleton of the molecule, determined the enzyme inhibitory potential of these compounds. The planar conformation of the molecules allows them to fit deep inside the pocket while blocking the entry of other physiological substrates seems to play an important role in their activity.