Molecular Diversity

, Volume 13, Issue 4, pp 399–419

One hundred years of Meldrum’s acid: advances in the synthesis of pyridine and pyrimidine derivatives

Review

DOI: 10.1007/s11030-009-9136-x

Cite this article as:
Lipson, V.V. & Gorobets, N.Y. Mol Divers (2009) 13: 399. doi:10.1007/s11030-009-9136-x

Abstract

A general review (138 references) focused on the recent advances in the application of Meldrum’s acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-like molecules is presented.

Keywords

Meldrum’s acidPyridinePyrimidineAzoloazinesTandem reactionsMulticomponent cyclocondensations

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.State Institution “V.Ya. Danilevsky Institute of Endocrine Pathology Problems”Academy of Medical Sciences of UkraineKharkovUkraine
  2. 2.Department of Chemistry of Heterocyclic CompoundsState Scientific Institution “Institute for Single Crystals”, National Academy of Sciences of UkraineKharkovUkraine
  3. 3.AG Limbach, Institute for Organic ChemistryFree University of BerlinBerlinGermany