Metabolic Brain Disease

, Volume 20, Issue 1, pp 73–80

Chronic Hyperprolinemia Provokes a Memory Deficit in the Morris Water Maze Task

  • Caren Serra Bavaresco
  • Emílio Luíz Streck
  • Carlos Alexandre Netto
  • Angela Terezinha Souza de Wyse
Article

DOI: 10.1007/s11011-005-2478-x

Cite this article as:
Bavaresco, C.S., Luíz Streck, E., Netto, C.A. et al. Metab Brain Dis (2005) 20: 73. doi:10.1007/s11011-005-2478-x

Abstract

In the present study we investigated the effect of chronic proline (Pro) administration on rat performance in the Morris water maze task. Rats received s.c. injections of Pro twice a day at 8 h intervals from the 6th to the 28th days of age and equivalent volume of 0.9% saline solution (control). On the 60th day of life, rats were subjected to the water maze task. Results showed that chronic Pro administration provokes impairment on spatial learning, as shown by the increase of latency in acquisition and retention and by a reduced efficiency to find the platform position in the working memory test. Present results suggest that hyperprolininemia causes cognitive dysfunction and might be relevant to explain, at least in part, the neurological dysfunction associated with hyperprolinemia.

Keywords

Hyperprolinemia type IIprolinememorywater mazerats

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Caren Serra Bavaresco
    • 1
  • Emílio Luíz Streck
    • 1
  • Carlos Alexandre Netto
    • 1
  • Angela Terezinha Souza de Wyse
    • 1
    • 2
  1. 1.Department of BiochemistryICBS, Universidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Departamento de BioquímicaICBS, Universidade Federal do Rio Grande do SulPorto AlegreBrazil