Article

Molecular and Cellular Biochemistry

, Volume 374, Issue 1, pp 157-161

Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells

  • Takashi ShimizuAffiliated withGraduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Email author 
  • , Eri ImamuraAffiliated withGraduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
  • , Fumie MagataAffiliated withGraduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
  • , Chiaki MurayamaAffiliated withGraduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
  • , Akio MiyamotoAffiliated withGraduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine

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Abstract

Interleukin 8 (IL-8) is a chemoattractant associated with ovulation in the mammalian ovary. This chemokine is also involved in the recruitment and activation of neutrophils. Using bovine tissue, we examined the possible role of IL-8 in steroid production by theca cells of the large ovarian follicles. IL-8 promoted progesterone production and stimulated StAR expression in cultured theca cells. The inhibitor of p38 did not disturb the P4 production and StAR expression in IL-8-treated theca cells. On the other hand, the inhibitor of MEK disturbed the P4 production and expression of StAR in theca cells treated with IL-8. These results suggest that IL-8 is associated with progesterone production in bovine theca cells via the MEK pathway.

Keywords

IL-8 Progesterone StAR p38 MEK Theca cell