Molecular and Cellular Biochemistry

, Volume 365, Issue 1, pp 85–92

Antioxidant activity of β-selenoamines and their capacity to mimic different enzymes

  • Alessandro de Souza Prestes
  • Sílvio Terra Stefanello
  • Syed M. Salman
  • Andréia Martini Pazini
  • Ricardo S. Schwab
  • Antônio Luiz Braga
  • Nilda Berenice de Vargas Barbosa
  • João B. T. Rocha
Article

DOI: 10.1007/s11010-012-1246-6

Cite this article as:
de Souza Prestes, A., Stefanello, S.T., Salman, S.M. et al. Mol Cell Biochem (2012) 365: 85. doi:10.1007/s11010-012-1246-6

Abstract

The antioxidant properties of organoselenium compounds have been extensively investigated because oxidative stress is a hallmark of a variety of chronic human diseases. Here, we reported the influence of substituent groups in the antioxidant activity of β-selenoamines. We have investigated whether they exhibited glutathione peroxidase-like (GPx-like) activity and whether they could be substrate of thioredoxin reductase (TrxR). In the DPPH assay, the β-selenium amines did not exhibit antioxidant activity. However, the β-selenium amines with p-methoxy and tosyl groups prevented the lipid peroxidation. The β-selenium amine compound with p-methoxy substituent group exhibited thiol-peroxidase-like activity (GPx-like activity) and was reduced by the hepatic TrxR. These results contribute to understand the influence of structural alteration of non-conventional selenium compounds as synthetic mimetic of antioxidant enzymes of mammalian organisms.

Keywords

AntioxidantsEnzymesSelenoamines

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Alessandro de Souza Prestes
    • 1
  • Sílvio Terra Stefanello
    • 1
  • Syed M. Salman
    • 2
  • Andréia Martini Pazini
    • 1
  • Ricardo S. Schwab
    • 1
  • Antônio Luiz Braga
    • 1
  • Nilda Berenice de Vargas Barbosa
    • 1
  • João B. T. Rocha
    • 1
  1. 1.Departamento de Química, Centro de Ciências Naturais e ExatasUniversidade Federal de Santa MariaSanta MariaBrazil
  2. 2.Islamia College UniversityKPKPakistan