Molecular and Cellular Biochemistry

, Volume 357, Issue 1, pp 247–253

HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women

  • Anna P. Batschauer
  • Nathalia G. Cruz
  • Vanessa C. Oliveira
  • Fernanda F. Coelho
  • Izabela R. Santos
  • Michelle T. Alves
  • Ana P. Fernandes
  • Maria G. Carvalho
  • Karina B. Gomes
Article

DOI: 10.1007/s11010-011-0895-1

Cite this article as:
Batschauer, A.P., Cruz, N.G., Oliveira, V.C. et al. Mol Cell Biochem (2011) 357: 247. doi:10.1007/s11010-011-0895-1

Abstract

Genetic factors related to cancer have been extensively studied and several polymorphisms have been associated to breast cancer. The FGFR4, MTHFR, and HFE genes have been associated with neoplastic diseases development. The current report outlines the analysis of the polymorphisms G388A (FGFR4), C677T (MTHFR), C282Y, and H63D (HFE) in Brazilian breast cancer patients. We studied 68 patients with invasive ductal and operable breast carcinoma and 85 women as a control group. The polymorphism frequencies in the breast cancer and control groups were analyzed, but no significant difference was observed by comparing the two groups. The presence of each polymorphism was analyzed according to the clinical features and markers already established as prognostic in the breast cancer group. The C677T, H63D, and G388A polymorphisms were not associated to histological grade, age of diagnosis, expression of HER2 receptor, or estrogen and progesterone receptor. The H63D polymorphism showed a significant association (P = 0.02) with the presence of p53 mutations, and C667T showed association to lymph node involvement (P = 0.05). Lymph node involvement, G388A polymorphism, and histological grade were independently associated to metastasis/death. Our data suggests that the polymorphisms G388A, C677T, and H63D are not useful in breast cancer diagnosis, but they may be significant additional prognostic markers related to breast cancer survival.

Keywords

Breast cancerFGFR4MTHFRHFEPrognostic markers

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Anna P. Batschauer
    • 1
  • Nathalia G. Cruz
    • 1
  • Vanessa C. Oliveira
    • 2
  • Fernanda F. Coelho
    • 1
  • Izabela R. Santos
    • 1
  • Michelle T. Alves
    • 1
  • Ana P. Fernandes
    • 1
  • Maria G. Carvalho
    • 1
  • Karina B. Gomes
    • 1
  1. 1.Department of Clinical and Toxicological AnalysisFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Department of GeneticsHermes Pardini InstituteBelo HorizonteBrazil