Molecular and Cellular Biochemistry

, Volume 344, Issue 1, pp 185–193

Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases

  • José D. Méndez
  • Jianling Xie
  • Montserrat Aguilar-Hernández
  • Verna Méndez-Valenzuela

DOI: 10.1007/s11010-010-0541-3

Cite this article as:
Méndez, J.D., Xie, J., Aguilar-Hernández, M. et al. Mol Cell Biochem (2010) 344: 185. doi:10.1007/s11010-010-0541-3


The modification of free amino groups on proteins, lipids, and nucleic acids by non-enzymatic glycosylation produce a variety of complex structures named advanced glycation end products (AGEs). Glycation of these molecules participate in the development of diabetic complications and related diseases. Diabetes mellitus is characterized by short-term metabolic changes in lipid and protein metabolism, and long-term irreversible changes in vascular and connective tissue. AGEs are directly implicated in the development of chronic complications in diabetes such as nephropathy, rethinopathy, neuropathy, and other related diseases such as atherosclerosis, heart disease, stroke, and peripheral vascular disease. In this review, we aim to explain how glycation occurs in different molecules and what the pathological consequence of AGE formation in diabetes mellitus and other diseases are.


Advanced glycation end productsHyperglycemiaDiabetes mellitusProteinsLipidsNucleic acidsChronic complications

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • José D. Méndez
    • 1
  • Jianling Xie
    • 2
  • Montserrat Aguilar-Hernández
    • 3
  • Verna Méndez-Valenzuela
    • 4
  1. 1.Medical Research Unit in Metabolic Diseases, National Medical CenterMexican Institute of Social SecurityMexicoMexico
  2. 2.Department of Cell Physiology and Pharmacology, College of Medicine, Biological Sciences and PsychologyUniversity of LeicesterLeicesterUK
  3. 3.Department of Biochemistry, College of Medicine, Biological Sciences and PsychologyUniversity of LeicesterLeicesterUK
  4. 4.Division of DiabetesUniversity of Texas Health Science Center at San Antonio (UTHSCSA)San AntonioUSA