Molecular and Cellular Biochemistry

, Volume 334, Issue 1, pp 67–80

Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

Authors

  • Nirmalya Basu
    • Department of Molecular Reproduction, Development and GeneticsIndian Institute of Science
  • Najla Arshad
    • Department of Molecular Reproduction, Development and GeneticsIndian Institute of Science
    • Department of Molecular Reproduction, Development and GeneticsIndian Institute of Science
Article

DOI: 10.1007/s11010-009-0324-x

Cite this article as:
Basu, N., Arshad, N. & Visweswariah, S.S. Mol Cell Biochem (2010) 334: 67. doi:10.1007/s11010-009-0324-x

Abstract

Receptor guanylyl cyclase C (GC-C) is the target for the gastrointestinal hormones, guanylin, and uroguanylin as well as the bacterial heat-stable enterotoxins. The major site of expression of GC-C is in the gastrointestinal tract, although this receptor and its ligands play a role in ion secretion in other tissues as well. GC-C shares the domain organization seen in other members of the family of receptor guanylyl cyclases, though subtle differences highlight some of the unique features of GC-C. Gene knock outs in mice for GC-C or its ligands do not lead to embryonic lethality, but modulate responses of these mice to stable toxin peptides, dietary intake of salts, and development and differentiation of intestinal cells. It is clear that there is much to learn in future about the role of this evolutionarily conserved receptor, and its properties in intestinal and extra-intestinal tissues.

Keywords

Guanylyl cyclase C Guanylin Uroguanylin Stable toxin peptides cGMP

Copyright information

© Springer Science+Business Media, LLC. 2009