Molecular and Cellular Biochemistry

, Volume 329, Issue 1, pp 51-62

First online:

The mammalian Nm23/NDPK family: from metastasis control to cilia movement

  • Mathieu BoissanAffiliated withINSERM UMRS_938, UMPC Université Paris 06
  • , Sandrine DabernatAffiliated withINSERM U876, Université de Bordeaux-2
  • , Evelyne PeuchantAffiliated withINSERM U876, Université de Bordeaux-2
  • , Uwe SchlattnerAffiliated withINSERM U884, Université Joseph Fourier
  • , Ioan LascuAffiliated withInstitut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Université de Bordeaux-2
  • , Marie-Lise LacombeAffiliated withINSERM UMRS_938, UMPC Université Paris 06 Email author 

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Nucleoside diphosphate kinases (NDPK) are encoded by the NME genes, also called NM23. They catalyze the transfer of γ-phosphate from nucleoside triphosphates to nucleoside diphosphates by a ping-pong mechanism involving the formation of a high energy phospho-histidine intermediate [1, 2]. Besides their known functions in the control of intracellular nucleotide homeostasis, they are involved in multiple physiological and pathological cellular processes such as differentiation, development, metastastic dissemination or cilia functions. Over the past 15 years, ten human genes have been discovered encoding partial, full length, and/or tandemly repeated Nm23/NDPK domains, with or without N-or C-terminal extensions and/or additional domains. These genes encode proteins exhibiting different functions at various tissular and subcellular localizations. Most of these genes appear late in evolution with the emergence of the vertebrate lineage. This review summarizes the present knowledge on these multitalented proteins.


Nucleoside diphosphate kinase Signaling Cancer Mitochondria Phospholipid