NF-κB controls growth of glioblastomas/astrocytomas
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- Smith, D., Shimamura, T., Barbera, S. et al. Mol Cell Biochem (2008) 307: 141. doi:10.1007/s11010-007-9593-4
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NF-κB is a family of transcription factors that have been shown to be elevated in a variety of tumor types and in some cases central to their survival and growth. Here we present evidence that U-87 MG and U-118 MG growth is regulated by NF-κB and controlled by PDGF. NF-κB activity was suppressed by a dominant negative mutant of the human PDGF type β receptor and PDGF-B chain neutralizing antibodies. Creation of cell lines that had inducible expression of shRNAs directed against either c-Rel or RelA inhibited growth almost 90% indicating that NF-κB plays a central role in glioblastoma growth.