Molecular and Cellular Biochemistry

, Volume 307, Issue 1, pp 141–147

NF-κB controls growth of glioblastomas/astrocytomas

  • Denise Smith
  • Takeshi Shimamura
  • Stephanie Barbera
  • Bruce E. Bejcek
Article

DOI: 10.1007/s11010-007-9593-4

Cite this article as:
Smith, D., Shimamura, T., Barbera, S. et al. Mol Cell Biochem (2008) 307: 141. doi:10.1007/s11010-007-9593-4

Abstract

NF-κB is a family of transcription factors that have been shown to be elevated in a variety of tumor types and in some cases central to their survival and growth. Here we present evidence that U-87 MG and U-118 MG growth is regulated by NF-κB and controlled by PDGF. NF-κB activity was suppressed by a dominant negative mutant of the human PDGF type β receptor and PDGF-B chain neutralizing antibodies. Creation of cell lines that had inducible expression of shRNAs directed against either c-Rel or RelA inhibited growth almost 90% indicating that NF-κB plays a central role in glioblastoma growth.

Keywords

PDGFNF-κBGlioblastoma

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Denise Smith
    • 1
  • Takeshi Shimamura
    • 2
  • Stephanie Barbera
    • 1
  • Bruce E. Bejcek
    • 1
  1. 1.Department of Biological SciencesWestern Michigan UniversityKalamazooUSA
  2. 2.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA