Molecular and Cellular Biochemistry

, Volume 293, Issue 1, pp 71–78

Changes of collagen metabolism predict the left ventricular remodeling after myocardial infarction

  • Jirmar Radovan
  • Pelouch Vaclav
  • Widimsky Petr
  • Capek Jan
  • Andel Michal
  • Prusa Richard
  • Pechova Martina
Article

DOI: 10.1007/s11010-006-2955-5

Cite this article as:
Radovan, J., Vaclav, P., Petr, W. et al. Mol Cell Biochem (2006) 293: 71. doi:10.1007/s11010-006-2955-5

Abstract

Objectives: To analyze the predictive value of cardiac collagen metabolism “in vivo" in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). Design: Forty-five patients (age 66 ± 8.27) underwent biochemical analysis for cardiac collagen metabolism (groups A, B and C); 30 patients with their first MI were treated with successful PCI (group A; n = 30), group B (n = 5) were MI patients with unsuccessful PCI. Group C were patients without MI (n = 10), they underwent elective diagnostic coronary angiography only. The collagen metabolism was analyzed in acute and subacute MI phases by using serum blood markers: the carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP) and carboxy-terminal telopeptide of type I collagen (ICTP). Furthermore, the ejection fraction (EF) and left ventricular end-diastolic volume maximal changes in the course of 6 months were measured by echocardiography. Results: A significant increase of both PICP and PIIINP on day 4 following MI was detected. Furthermore, PICP and PIIINP level assessed on the 30th day was significantly higher in the PCI unsuccessful group versus successful group. PICP level on day 4 above 110 ug/l and PIIINP level above 4 ug/l was significantly often found in the subgroup of patients with the EF improvement less than 10% or worsening and with significant left ventricular dilatation during 6 months follow-up. Cardiac catheterization itself does not affect collagen metabolism. Conclusion: We concluded that collagen metabolism markers enable to study in vivo the MI healing and to predict left ventricular functional and volume changes.

Key words

collagen coronary revascularization human heart left ventricular remodeling myocardial infarction 

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Jirmar Radovan
    • 1
  • Pelouch Vaclav
    • 2
    • 3
  • Widimsky Petr
    • 1
  • Capek Jan
    • 1
  • Andel Michal
    • 4
  • Prusa Richard
    • 5
  • Pechova Martina
    • 5
  1. 1.Cardiocenter, Department of Cardiology, 3rd Medical SchoolCharles University and University Hospital Kralovske VinohradyPragueCzech Republic, Europe
  2. 2.Department of Medical Chemistry and Biochemistry of the 2nd Faculty of MedicineCharles UniversityPragueCzech Republic
  3. 3.Centre for Cardiovascular Research of the 2nd Faculty of MedicineCharles UniversityPragueCzech Republic
  4. 4.2nd Internal Clinic of the University Hospital Kralovske Vinohrady and the 3rd Medical SchoolCharles UniversityPragueCzech Republic
  5. 5.Department of Clinical Biochemistry and Pathobiochemistry of the 2nd Medical SchoolCharles UniversityPragueCzech Republic

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