Molecular and Cellular Biochemistry

, Volume 285, Issue 1, pp 143–147

Effect of ascorbic acid on prevention of hypercholesterolemia induced atherosclerosis

Article

DOI: 10.1007/s11010-005-9070-x

Cite this article as:
Das, S., Ray, R., Snehlata et al. Mol Cell Biochem (2006) 285: 143. doi:10.1007/s11010-005-9070-x

Abstract

The notion that oxidation of lipids and propagation of free radicals may contribute to the pathogenesis of atherosclerosis is supported by a large body of evidence. To circumvent the damage caused by oxygen free radicals, antioxidants are needed which provide the much needed neutralization of free radical by allowing the pairing of electrons. In this study we have investigated the effect of ascorbic acid, a water soluble antioxidant on the development of hypercholesterolemia induced atherosclerosis in rabbits. Rabbits were made hypercholesterolemic and atherosclerotic by feeding 100 mg cholesterol/day. Different doses of ascorbic acid were administered to these rabbits. Low dose of ascorbic acid (0.5 mg/100 g body weight/day) did not have any significant effect on the percent of total area covered by atherosclerotic plaque. However, ascorbic acid when fed at a higher dose (15 mg/100 g body weight/day) was highly effective in reducing the atherogenecity. With this dose the percent of total surface area covered by atherosclerotic plaque was significantly less (p < 0.001). This suggests that use of ascorbic acid may have great promise in the prevention of hypercholesterolemia induced atherosclerosis.

Keywords

ascorbic acidatherosclerosishypercholesterolemia

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • S. Das
    • 1
    • 5
  • R. Ray
    • 2
  • Snehlata
    • 3
  • N. Das
    • 1
    • 5
  • L. M. Srivastava
    • 1
    • 4
    • 5
  1. 1.Department of BiochemistrySir Ganga Ram HospitalNew DelhiIndia
  2. 2.Department of PathologySir Ganga Ram HospitalNew DelhiIndia
  3. 3.Department of Nuclear MedicineAll India Institute of Medical SciencesNew DelhiIndia
  4. 4.Department of BiochemistrySir Ganga Ram HospitalNew DelhiIndia
  5. 5.All India Institute of Medical SciencesNew DelhiIndia