Molecular and Cellular Biochemistry

, Volume 284, Issue 1, pp 135–140

Translocation of long chain fatty acids across the plasma membrane – lipid rafts and fatty acid transport proteins

  • Robert Ehehalt
  • Joachim Füllekrug
  • Jürgen Pohl
  • Axel Ring
  • Thomas Herrmann
  • Wolfgang Stremmel
Article

DOI: 10.1007/s11010-005-9034-1

Cite this article as:
Ehehalt, R., Füllekrug, J., Pohl, J. et al. Mol Cell Biochem (2006) 284: 135. doi:10.1007/s11010-005-9034-1
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Abstract

Translocation of long chain fatty acids across the plasma membrane is achieved by a concert of co-existing mechanisms. These lipids can passively diffuse, but transport can also be accelerated by certain membrane proteins as well as lipid rafts. Lipid rafts are dynamic assemblies of proteins and lipids, that float freely within the two dimensional matrix of the membrane bilayer. They are receiving increasing attention as devices that regulate membrane function in vivo and play an important role in membrane trafficking and signal transduction. In this review we will discuss how lipid rafts might be involved in the uptake process and how the candidate proteins for fatty acid uptake FAT/CD36 and the FATP proteins interact with these domains. We will also discuss the functional role of FATPs in general. To our understanding FATPs are indirectly involved in the translocation process across the plasma membrane by providing long chain fatty acid synthetase activity.

Keywords

lipid rafts cholesterol caveolae FAT/CD36 FATP long chain fatty acid uptake 

Abbreviation

LCAFs

long chain fatty acids

FATP

fatty acid transport protein

DRM

detergent resistant membrane

CAVDGV

dominant negative caveolin-1 mutant

SSO

sulfo-N-succinimidyl oleate

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Robert Ehehalt
    • 1
    • 2
  • Joachim Füllekrug
    • 1
  • Jürgen Pohl
    • 1
  • Axel Ring
    • 1
  • Thomas Herrmann
    • 1
  • Wolfgang Stremmel
    • 1
  1. 1.Department of Internal Medicine IV (Gastroenterology)University of HeidelbergHeidelbergGermany
  2. 2.Department of Gastroenterology, Hepatology and Infectious DiseasesUniversity of HeidelbergHeidelbergGermany