Molecular and Cellular Biochemistry

, Volume 284, Issue 1, pp 81–85

Evaluation of the effects of cadmium on rat liver

Authors

    • Department of Physiology, Faculty of MedicineSuleyman Demirel University
    • Department of Physiology, Suleyman Demirel UniversitySchool of Medicine
  • Alpaslan Gokcimen
    • Department of Histology and Embryology, Faculty of MedicineSuleyman Demirel University
  • Fehmi Ozguner
    • Department of Physiology, Faculty of MedicineSuleyman Demirel University
  • Dilek Senal Bayram
    • Department of Histology and Embryology, Faculty of MedicineSuleyman Demirel University
  • Ahmet Kocak
    • Department of Histology and Embryology, Faculty of MedicineSuleyman Demirel University
Article

DOI: 10.1007/s11010-005-9017-2

Cite this article as:
Koyu, A., Gokcimen, A., Ozguner, F. et al. Mol Cell Biochem (2006) 284: 81. doi:10.1007/s11010-005-9017-2

Abstact

Cadmium is one of the most toxic pollutants in environment. Cadmium accumulation in blood affects the renal cortex and causes renal failure. In this study, we aimed to evaluate the effects of cadmium on rat liver tissue. Eighteen male albino rats aged ten weeks old were used in the study. 15 ppm of cadmium was administered to rats via consumption water daily. At the end of the 30th study day, the animals were killed under ether anesthesia. After the liver tissue samples were taken, histopathological and biochemical examinations were performed. Histopathologic changes have included vacuolar and granular degenerations in hepatocytes, heterochromatic nucleuses and sinusoidal and portal widenings. Central vein diameters were normal in cadmium exposed group. Whereas, there was statistically significant difference between two groups by means of sinusoidal (p< 0.001) and portal triad diameters (p< 0.01). Malondialdehyde (MDA) is an indicator of lipid peroxidation. In this study, MDA was used as a marker of oxidative stress-induced liver impairment in cadmium exposed rats. Superoxide dismutase (SOD) and catalase (CAT) activities were also measured to evaluate the changes in antioxidative system in liver tissues. Current findings showed that MDA levels were increased and SOD and CAT activities were decreased in cadmium exposed group compared to control group. The difference between two groups was statistically significant (pvalues: MDA,p< 0.01; CAT,p< 0.01 and SOD,p< 0.05). In conclusion, these findings suggest the role of oxidative mechanisms in cadmium-induced liver tissue damage

Keywords

cadmiumhistopathologic changesliveroxidative stress

Copyright information

© Springer Science+Business Media, Inc. 2005