‘Why do tumour cells glycolyse?’: From glycolysis through citrate to lipogenesis

  • Leslie C. Costello
  • Renty B. Franklin
Review

DOI: 10.1007/s11010-005-8841-8

Cite this article as:
Costello, L.C. & Franklin, R.B. Mol Cell Biochem (2005) 280: 1. doi:10.1007/s11010-005-8841-8

Abstract

The re-emergence of interest in intermediary metabolism and the development of metabolomics in relation to cancer and other diseases provide a timely reason to revisit issues of tumour cell metabolism. In this review, we address the issue of the role of high aerobic glycolysis, which is commonly associated with the metabolism of many tumour cells. The concept presented emphasises the importance of the glycolysis-citrate-lipogenesis pathway in providing the synthetic and bioenergetic requirements that are essential for the growth and proliferation of tumour cells. We hope that our discussion will be informative and instructive, and will stimulate interest and research regarding the intermediary metabolism and its regulation in tumour cells. We express our appreciation to the many pioneering and contemporary researchers whose studies provide much of the basis for this presentation. (Mol Cell Biochem xxx: 1–8, 2005)

Keyword

tumour cell metabolismglycolysislipogenesiscitratem-aconitaseprostate cell metabolismmitochondrial citrate export

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Leslie C. Costello
    • 1
    • 2
  • Renty B. Franklin
    • 1
  1. 1.Department of Biomedical SciencesDental School/University of MarylandBaltimoreMaryland
  2. 2.Department of Biomedical SciencesDental School/University of MarylandBaltimore