Maternal and Child Health Journal

, Volume 18, Issue 6, pp 1454–1461

Pandemic Influenza A (H1N1) in Non-vaccinated, Pregnant Women in Spain (2009–2010)

  • María Morales-Suárez-Varela
  • Fernando González-Candelas
  • Jenaro Astray
  • Jordi Alonso
  • Ady Castro
  • Rafael Cantón
  • Juan Carlos Galán
  • Olatz Garin
  • Núria Soldevila
  • Maretva Baricot
  • Jesús Castilla
  • Pere Godoy
  • Miguel Delgado-Rodríguez
  • Vicente Martín
  • José María Mayoral
  • Tomás Pumarola
  • José Maria Quintana
  • Sonia Tamames
  • Agustín Llopis-González
  • Ángela Domínguez
  • the CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
Article

DOI: 10.1007/s10995-013-1385-8

Cite this article as:
Morales-Suárez-Varela, M., González-Candelas, F., Astray, J. et al. Matern Child Health J (2014) 18: 1454. doi:10.1007/s10995-013-1385-8
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Abstract

The aim of this study was to investigate the main characteristics of non-vaccinated pregnant women who were hospitalised for influenza A (H1N1) pdm09 pandemic versus pregnant women hospitalised for non-influenza-related reasons in Spain, and to characterise the clinical presentation of the disease in this population to facilitate early diagnosis and future action programmes. Understanding influenza infection during pregnancy is important as pregnant women are a high-risk population for increased morbidity from influenza infection. We investigated the socio-demographic and clinical features of 51 non-vaccinated, pregnant women infected with the pandemic influenza A (H1N1) virus in Spain (cases) and compared them to 114 controls (non-vaccinated and non-infected pregnant women) aged 15–44 years. Substantial and significant odd ratios (ORs) for pandemic influenza A (H1N1) were found for the pregnant women who were obese compared with controls (body mass index > 30) (OR 3.03; 95 % confidence intervals 1.13–8.11). The more prevalent symptoms observed in pandemic influenza-infected pregnant women were high temperature, cough (82.4 %), malaise (80.5 %), myalgia (56.1 %), and headaches (54.9 %). Our results suggest that the initial symptoms and risk factors for infection of pregnant women with the influenza A (H1N1) pdm09 virus are similar to the symptoms and risk factors for seasonal influenza, which make early diagnosis difficult, and reinforces the need to identify and protect high-risk groups.

Keywords

Influenza A (H1N1)PregnancyPandemicSymptomatologyClinical characteristics

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • María Morales-Suárez-Varela
    • 1
    • 2
    • 3
  • Fernando González-Candelas
    • 2
    • 3
    • 4
  • Jenaro Astray
    • 5
  • Jordi Alonso
    • 2
    • 6
    • 7
  • Ady Castro
    • 8
  • Rafael Cantón
    • 2
    • 9
  • Juan Carlos Galán
    • 2
    • 7
  • Olatz Garin
    • 6
    • 2
  • Núria Soldevila
    • 2
  • Maretva Baricot
    • 2
  • Jesús Castilla
    • 2
    • 10
  • Pere Godoy
    • 2
    • 11
  • Miguel Delgado-Rodríguez
    • 2
    • 12
  • Vicente Martín
    • 2
    • 13
  • José María Mayoral
    • 14
  • Tomás Pumarola
    • 15
  • José Maria Quintana
    • 2
    • 16
  • Sonia Tamames
    • 17
  • Agustín Llopis-González
    • 1
    • 2
    • 3
  • Ángela Domínguez
    • 2
    • 18
  • the CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
  1. 1.Unit of Public Health and Environmental Care, Department of Preventive MedicineUniversity of ValenciaBurjassotSpain
  2. 2.CIBER Epidemiology and Public Health (CIBERESP)MadridSpain
  3. 3.Center for Public Health Research (CSISP)ValenciaSpain
  4. 4.Research Unit in “Genomics and Health”, CSISPUniversity of ValenciaBurjassotSpain
  5. 5.Subdirección de Vigilancia, Comunidad de MadridMadridSpain
  6. 6.Universitat Pompeu FabraBarcelonaSpain
  7. 7.IMIM-Institut de Recerca de l’Hospital del MarBarcelonaSpain
  8. 8.CIBER Enfermedades RespiratoriasMadridSpain
  9. 9.Hospital Universitario Ramón y CajalMadridSpain
  10. 10.Instituto de Salud Pública de NavarraPamplonaSpain
  11. 11.Departament de Salut, Generalitat de CatalunyaBarcelonaSpain
  12. 12.Universidad de JaénJaénSpain
  13. 13.Universidad de LeónLeónSpain
  14. 14.Servicio de Vigilancia de AndalucíaSevilleSpain
  15. 15.Red Española de Investigación en Patología Infecciosa (REIPI)BarcelonaSpain
  16. 16.Fundación Vasca de Innovación e Investigación SanitariasSondika BizkaiaSpain
  17. 17.Dirección General de Salud Pública, Desarrollo e Innovación, Junta de Castilla y LeónValladolidSpain
  18. 18.Department of Public HealthUniversity of BarcelonaBarcelonaSpain