Maternal and Child Health Journal

, Volume 11, Issue 5, pp 461–473

Prenatal Programming of Childhood Overweight and Obesity

  • Jennifer S. Huang
  • Tiffany A. Lee
  • Michael C. Lu
Original Paper

DOI: 10.1007/s10995-006-0141-8

Cite this article as:
Huang, J.S., Lee, T.A. & Lu, M.C. Matern Child Health J (2007) 11: 461. doi:10.1007/s10995-006-0141-8

Abstract

Objective: To review the scientific evidence for prenatal programming of childhood overweight and obesity, and discuss its implications for MCH research, practice, and policy.

Methods: A systematic review of observational studies examining the relationship between prenatal exposures and childhood overweight and obesity was conducted using MOOSE guidelines. The review included literature posted on PubMed and MDConsult and published between January 1975 and December 2005. Prenatal exposures to maternal diabetes, malnutrition, and cigarette smoking were examined, and primary study outcome was childhood overweight or obesity as measured by body mass index (BMI) for children ages 5 to 21.

Results: Four of six included studies of prenatal exposure to maternal diabetes found higher prevalence of childhood overweight or obesity among offspring of diabetic mothers, with the highest quality study reporting an odds ratio of adolescent overweight of 1.4 (95% CI 1.0–1.9). The Dutch famine study found that exposure to maternal malnutrition in early, but not late, gestation was associated with increased odds of childhood obesity (OR 1.9, 95% CI 1.5–2.4). All eight included studies of prenatal exposure to maternal smoking showed significantly increased odds of childhood overweight and obesity, with most odds ratios clustering around 1.5 to 2.0. The biological mechanisms mediating these relationships are unknown but may be partially related to programming of insulin, leptin, and glucocorticoid resistance in utero.

Conclusion: Our review supports prenatal programming of childhood overweight and obesity. MCH research, practice, and policy need to consider the prenatal period a window of opportunity for obesity prevention.

Keywords

Prenatal programming Childhood obesity Overweight Developmental programming Fetal programming Gestational diabetes Maternal malnutrition Cigarette smoking 

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Jennifer S. Huang
    • 1
  • Tiffany A. Lee
    • 1
  • Michael C. Lu
    • 1
    • 2
  1. 1.Department of Obstetrics and GynecologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of Community Health Sciences and the Center for Healthier Children, Families and CommunitiesUCLA School of Public HealthLos AngelesUSA