Journal of Thermal Analysis and Calorimetry

, Volume 113, Issue 1, pp 259–264

Differential scanning calorimetry (DSC) of blood serum in chronic obstructive pulmonary disease (COPD)

A new diagnostic tool ahead?
  • Zsuzsanna Szalai
  • Tamás F. Molnár
  • Dénes Lőrinczy
Article

DOI: 10.1007/s10973-013-2999-1

Cite this article as:
Szalai, Z., Molnár, T.F. & Lőrinczy, D. J Therm Anal Calorim (2013) 113: 259. doi:10.1007/s10973-013-2999-1

Abstract

Chronic obstructive pulmonary disease (COPD) is a major global health challenge with a gloom perspective of being one of the big three cause of death by 2020. No reliable/reproducible biomarker has been identified so far to match the clinically-based staging system (GOLD). Blood samples of 30 subjects divided into 6 groups (no-COPD/-smoker, no-COPD/non-smoker, COPD I, COPD II, COPD III, COPD IV) with 5 patients in each were tested by differential scanning calorimetry. There is a clear 15.4 % difference between the heat flow maxima measured when no-COPD subjects were compared in accordance to their smoking/non-smoking status. Odds ratio of different heat flow in actively smoking COPD patients in stage IV and stage I was 1.61. A reverse tendency is detected in the relevant non-smoking COPD groups. The differences are inconsistent in intermediate stages (COPD II and III). DSC seems to be an applicable and objective method for monitoring nicotine abuse. There is a chance to detect specific typology of thermokinetic patterns in the two extremes of COPD (I vs. IV). Further studies with increased sample size are needed to allow calculations on specificity/sensitivity/positive and negative predictive value of enthalpies and heat flow maximums. The first clinically relevant blood-based COPD marker on the intravascular side of the alveo-capillary screen is demonstrated by our pilot study.

Keywords

Differential scanning calorimetry (DSC)Chronic obstructive pulmonary disease (COPD)COPD severityGlobal initiative for chronic obstructive lung disease (GOLD)

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2013

Authors and Affiliations

  • Zsuzsanna Szalai
    • 1
    • 2
  • Tamás F. Molnár
    • 3
  • Dénes Lőrinczy
    • 4
  1. 1.Department of PulmonologyPetz Aladár HospitalGyorHungary
  2. 2.Department of PulmonologyKarolina HospitalMosonmagyaróvárHungary
  3. 3.Thoracic Surgery Unit, Department of SurgeryPetz Aladár Teaching HospitalGyorHungary
  4. 4.Faculty of Medicine, Institute of BiophysicsUniversity of PécsPécsHungary