Journal of Thermal Analysis and Calorimetry

, Volume 102, Issue 2, pp 499–503

Thermal degradation of platinum(IV) precursors to antitumor drugs

  • B. A. Howell
  • P. Chhetri
  • A. Dumitrascu
  • K. N. Stanton
Article

DOI: 10.1007/s10973-010-0933-3

Cite this article as:
Howell, B.A., Chhetri, P., Dumitrascu, A. et al. J Therm Anal Calorim (2010) 102: 499. doi:10.1007/s10973-010-0933-3

Abstract

Organoplatinum antitumor agents are very effective, broad-spectrum drugs used for the treatment of a variety of cancerous conditions. The two most prominent of these, Cisplatin [cis-diamminodichloroplatinum(II)] and Carboplatin [diammino(1,1-cyclobutanedicarboxylato)platinum(II)], are large scale commercial successes. The third, Oxaliplatin [((trans-1,2-diamminocyclohexane)oxalato)platinum(II)], is now commercially available. The administration of all these drugs is accompanied by severe side effects. For Cisplatin, the most debilitating of these is kidney damage and extreme nausea. Several approaches to generate drug-release formulations that might mitigate toxic side effects have been explored. Now, platinum(IV) compounds which are more inert than platinum(II) compounds, and consequently less toxic, but which may be reduced to platinum(II) species within the cell are being evaluated for effectiveness in the treatment of cancer. The thermal stability of several precursors to compounds of this kind has been examined by thermogravimetry. In general, these materials lose ligands sequentially to generate a residue of platinum. This behavior may be generally useful for the characterization of such materials.

Keywords

Platinum(IV) prodrugsPlatinum(II) oxidationFunctionalized platinum drugsLigand labilityThermal stability

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2010

Authors and Affiliations

  • B. A. Howell
    • 1
    • 2
  • P. Chhetri
    • 1
    • 2
  • A. Dumitrascu
    • 1
    • 2
  • K. N. Stanton
    • 1
    • 2
  1. 1.Center for Applications in Polymer ScienceCentral Michigan UniversityMt. PleasantUSA
  2. 2.Department of ChemistryCentral Michigan UniversityMt. PleasantUSA