Journal of Structural and Functional Genomics

, Volume 8, Issue 2, pp 57–65

Structural genomics as an approach towards understanding the biology of tuberculosis

Original Paper

DOI: 10.1007/s10969-007-9020-9

Cite this article as:
Baker, E.N. J Struct Funct Genomics (2007) 8: 57. doi:10.1007/s10969-007-9020-9

Abstract

Tuberculosis (TB) is a devastating disease of worldwide importance. The availability of the genome sequence of Mycobacterium tuberculosis (Mtb), the causative agent, has stimulated a large variety of genome-scale initiatives. These include international structural genomics efforts which have the dual aim of characterising potential new drug targets and addressing key aspects of the biology of Mtb. This review highlights the various ways in which structural analysis has illuminated the biological activities of Mtb gene products, which were previously of unknown or uncertain function. Key information comes from the protein fold, from bound ligands, solvent molecules, ions etc. or from unexpectedly modified amino acid residues. Most importantly, the three dimensional structure of a protein permits the integration of data from many sources, both bioinformatic and experimental, to develop testable functional hypotheses. This has led to many new insights into TB biology.

Keywords

Crystal structures Function from structure Ligand binding Mycobacterium tuberculosis Protein folds Structural genomics TB biology 

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological SciencesUniversity of AucklandAucklandNew Zealand

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