Journal of Structural and Functional Genomics

, Volume 8, Issue 2, pp 37–44

Functional insights from structural genomics

Authors

  • Farhad Forouhar
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Alexandre Kuzin
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Jayaraman Seetharaman
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Insun Lee
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Weihong Zhou
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Mariam Abashidze
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Yang Chen
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Wei Yong
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
  • Haleema Janjua
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
  • Yingyi Fang
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
  • Dongyan Wang
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
  • Kellie Cunningham
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
  • Rong Xiao
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
  • Thomas B. Acton
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
  • Eran Pichersky
    • Department of Molecular, Cellular and Developmental BiologyUniversity of Michigan
  • Daniel F. Klessig
    • Boyce Thompson Institute for Plant Research
  • Carl W. Porter
    • Department of Pharmacology and TherapeuticsRoswell Park Cancer Institute
  • Gaetano T. Montelione
    • Center for Advanced Biotechnology and Medicine, Northeast Structural Genomics ConsortiumRutgers University
    • Department of Biological Sciences, Northeast Structural Genomics ConsortiumColumbia University
Original Paper

DOI: 10.1007/s10969-007-9018-3

Cite this article as:
Forouhar, F., Kuzin, A., Seetharaman, J. et al. J Struct Funct Genomics (2007) 8: 37. doi:10.1007/s10969-007-9018-3

Abstract

Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF_0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP_1951), and a 12-stranded β-barrel with a novel fold (V. parahaemolyticus VPA1032).

Keywords

MethyltransferaseSpermineAcetyltransferase

Copyright information

© Springer Science+Business Media B.V. 2007