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Synthesis of a 188Re–DTPMP complex using carrier-free 188Re and study of its stability

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Abstract

Labeling of diethylenetriamine-N,N,N′,N″,N″-pentakis(methylenephosphonic) acid (DTPMP) with rhenium-188 using stannous chloride as a reducing agent has been investigated. Dependence of the yield of the 188Re–DTPMP complex on the concentration of the reducing agent, pH, reaction time, temperature, ascorbic acid and amount of carrier added has been studied. Under optimum conditions, the labeling yield of 188Re–DTPMP complex is 95% for the carrier-free 188Re but with the carrier-added 188Re the labeling yield is more than 97%. Furthermore, the stability of the 188Re–DTPMP complex against pH change and dilution with saline has been also studied. It is found that the addition of carrier stabilizes the 188Re–DTPMP complex against pH change and dilution.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt

    M. Y. Nassar

  2. Labeled Compounds Department, Hot Labs Centre, Atomic Energy Authority, Cairo, Egypt

    M. T. El-Kolaly

  3. National Research Centre, Dokki, Cairo, Egypt

    M. R. H. Mahran

Authors
  1. M. Y. Nassar
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  2. M. T. El-Kolaly
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  3. M. R. H. Mahran
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Correspondence to M. Y. Nassar.

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Nassar, M.Y., El-Kolaly, M.T. & Mahran, M.R.H. Synthesis of a 188Re–DTPMP complex using carrier-free 188Re and study of its stability. J Radioanal Nucl Chem 287, 779–785 (2011). https://doi.org/10.1007/s10967-010-0933-6

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  • DOI: https://doi.org/10.1007/s10967-010-0933-6

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