Journal of Polymer Research

, 19:8

Dilute solution properties of some polycarboxybetaines with antibacterial activity

  • Anca Giorgiana Grigoras
  • Stefania Racovita
  • Silvia Vasiliu
  • Manuela Tatiana Nistor
  • Simona Dunca
  • Virgil Barboiu
  • Vasile Cristian Grigoras
Original Paper

DOI: 10.1007/s10965-012-0008-1

Cite this article as:
Grigoras, A.G., Racovita, S., Vasiliu, S. et al. J Polym Res (2012) 19: 8. doi:10.1007/s10965-012-0008-1

Abstract

The dilute solution properties of polymeric quaternary ammonium betaines derived from poly(N-vinylimidazole) PNVI and containing either a methylene (B1), ethylene (B2), or propylene (B3) betaine group, respectively, were analyzed. A PNVI blank was also tested. The weight-average molecular weight \( {{\overline{M}}_{\text{w}}} \), second virial coefficient A2, radius of gyration Rg, and hydrodynamic radius Rh of unfractionated probes were determined by MALLS (multiangle laser light scattering) and WALLS (wide-angle laser light scattering) measurements. All of these parameters varied with the type of solvent: pure water, an aqueous solution of 0.5 M NaCl, or an alcohol. These solution properties were useful for predicting the interactions of the polycarboxybetaines (acting as antimicrobial agents) with the components of the bacterial cell wall. Some of the polycarboxybetaines exhibited antimicrobial activities, as shown by the Kirby–Bauer diffusion method. A concentration of about 20 mg mL−1 for B1 or B3 in an aqueous solution of 0.5 M NaCl is sufficient to inhibit the growth of Escherichia coli.

Keywords

Antibacterial agentPolycarboxybetaineMALLSWALLS

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Anca Giorgiana Grigoras
    • 1
  • Stefania Racovita
    • 1
  • Silvia Vasiliu
    • 1
  • Manuela Tatiana Nistor
    • 1
  • Simona Dunca
    • 2
  • Virgil Barboiu
    • 1
  • Vasile Cristian Grigoras
    • 1
  1. 1.“Petru Poni” Institute of Macromolecular ChemistryIasiRomania
  2. 2.“Alexandru Ioan Cuza” University of Iasi, Faculty of BiologyIasiRomania